Topology Independent Comparison of Biomolecular 3D Structures

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Comparing CLICK alignments with those in the HOMSTRAD database

The performance of CLICK, in terms of structure overlap values, over 9537 pair-wise alignments collated from the HOMSTRAD database. CLICK values are compared to those of a) HOMSTRAD, b) MUSTANG, and c) SALIGN. The red diagonal line separates the cases where CLICK was better than or worse than the method compared.



Difficult cases of aligning homologous protein pairs

The comparison of the structure overlap values of CLICK against HOMSTRAD (white square), MUSTANG (red diamond), Geometric Hashing (blue triangle), DALI (yellow triangle), and SALIGN (brown triangle) over the 64 difficult pair-wise alignments from the HOMSTRAD database.

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Similar structure but different topology

The comparison of the structure overlap values of CLICK against MUSTANG (red diamond), Geometric Hashing (blue triangle), and DALI (yellow triangle) over 89 pair-wise alignments that are structurally similar but topologically different.

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