AppA Server

Analysis, comparison, visualization of contact residues & interfacial waters of antibody-antigen structures/models

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Comparison between contact residues of antibody structures 1cz8HL (blue) and 1bj1HL (pink)

Structure Overlap	RMSD	Z-score	#Contact Residues of 1cz8HL	#Contact Residues of 1bj1HL	Match Size	#Identical Residues
100.00%	0.26	29.40	26	26	26	23

Matched contact residues of antibody structures (identical residues are highlighted in red)

No.	Contact residues of 1cz8HL	Region Chothia of 1cz8HL	Contact residues of 1bj1HL	Region Chothia of 1bj1HL
1	TYR L 91	CDR-L3	TYR L 91	CDR-L3
2	SER L 92	CDR-L3	SER L 92	CDR-L3
3	THR L 93	CDR-L3	THR L 93	CDR-L3
4	VAL L 94	CDR-L3	VAL L 94	CDR-L3
5	TRP L 96	CDR-L3	TRP L 96	CDR-L3
6	THR H 30	CDR-H1	THR H 30	CDR-H1
7	HIS H 31	CDR-H1	ASN H 31	CDR-H1
8	TYR H 32	CDR-H1	TYR H 32	CDR-H1
9	GLY H 33	Framework	GLY H 33	Framework
10	TRP H 47	Framework	TRP H 47	Framework
11	TRP H 50	Framework	TRP H 50	Framework
12	ASN H 52	CDR-H2	ASN H 52	CDR-H2
13	THR H 53	CDR-H2	THR H 53	CDR-H2
14	TYR H 54	CDR-H2	TYR H 54	CDR-H2
15	THR H 55	CDR-H2	THR H 55	CDR-H2
16	THR H 59	Framework	THR H 59	Framework
17	TYR H 99	CDR-H3	TYR H 99	CDR-H3
18	PRO H 100	CDR-H3	PRO H 100	CDR-H3
19	TYR H 101	CDR-H3	HIS H 101	CDR-H3
20	TYR H 102	CDR-H3	TYR H 102	CDR-H3
21	TYR H 103	CDR-H3	TYR H 103	CDR-H3
22	GLY H 104	CDR-H3	GLY H 104	CDR-H3
23	THR H 105	CDR-H3	SER H 105	CDR-H3
24	SER H 106	CDR-H3	SER H 106	CDR-H3
25	HIS H 107	CDR-H3	HIS H 107	CDR-H3
26	TRP H 108	CDR-H3	TRP H 108	CDR-H3


Matched contact residues		Superimposed structures		Mismatched contact residues

Comparison between contact residues of antigen structures 1cz8W (salmon) and 1bj1W (green)

Structure Overlap	RMSD	Z-score	#Contact Residues of 1cz8W	#Contact Residues of 1bj1W	Match Size	#Identical Residues
100.00%	0.15	20.40	19	17	17	17

Matched contact residues of antigen structures

No.	Contact residues of 1cz8W	Contact residues of 1bj1W
1	TYR W 45	TYR W 45
2	LYS W 48	LYS W 48
3	GLN W 79	GLN W 79
4	ILE W 80	ILE W 80
5	MET W 81	MET W 81
6	ARG W 82	ARG W 82
7	ILE W 83	ILE W 83
8	LYS W 84	LYS W 84
9	HIS W 86	HIS W 86
10	GLN W 87	GLN W 87
11	GLY W 88	GLY W 88
12	GLN W 89	GLN W 89
13	HIS W 90	HIS W 90
14	ILE W 91	ILE W 91
15	GLY W 92	GLY W 92
16	GLU W 93	GLU W 93
17	MET W 94	MET W 94


Matched contact residues		Superimposed structures		Mismatched contact residues