AppA Server

Structure 4ypg: Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody

Heavy chain: blue color; Antigen: salmon color; Contact residues: shown in sticks

Number of contact residues of heavy chain = 19

Contact residues of heavy chain have 7 Hbonds, 61 hydrophobic, 78 vdW, 0 ionic interactions with antigen, and 0 Hbonds with interfacial waters

No.	Contact Residues of Heavy Chain	Region Chothia	Secondary Structure	Solvent Accessibility	Number of Hbonds with Antigen	Number of Hydrophobic Interactions	Number of VdW Interactions	Number of Ionic Interactions	Number of Hbonds with Interfacial Waters
1	THR H 30	CDR-H1	Coil	Exposed	0	0	0	0	0
2	SER H 31	CDR-H1	Coil	Exposed	1	0	2	0	0
3	TYR H 32	CDR-H1	Strand	Exposed	1	6	12	0	0
4	SER H 33	Framework	Strand	Intermediate	1	0	3	0	0
5	TRP H 47	Framework	Strand	Exposed	0	4	2	0	0
6	TRP H 50	Framework	Strand	Exposed	0	20	6	0	0
7	SER H 52	CDR-H2	Strand	Intermediate	1	0	4	0	0
8	TYR H 54	CDR-H2	Coil	Exposed	0	5	6	0	0
9	ASN H 55	CDR-H2	Coil	Exposed	1	0	11	0	0
10	ASN H 57	CDR-H2	Strand	Exposed	2	0	8	0	0
11	THR H 58	Framework	Strand	Intermediate	0	0	0	0	0
12	ASN H 59	Framework	Strand	Exposed	0	1	2	0	0
13	ARG H 98	Framework	Strand	Buried	0	0	0	0	0
14	ASP H 99	CDR-H3	Strand	Exposed	0	1	1	0	0
15	PRO H 100	CDR-H3	Coil	Exposed	0	12	12	0	0
16	ILE H 101	CDR-H3	Coil	Exposed	0	0	1	0	0
17	ALA H 102	CDR-H3	Coil	Exposed	0	5	2	0	0
18	ALA H 103	CDR-H3	Coil	Intermediate	0	5	6	0	0
19	TYR H 105	CDR-H3	Coil	Exposed	0	2	0	0	0


Interactions of contact residues of heavy chain		Structure of contact residues of heavy chain		Detailed contact residues of heavy chain

Number of contact residues of antigen = 14

Contact residues of antigen have 7 Hbonds, 61 hydrophobic, 78 vdW, 0 ionic interactions with antibody, and 0 Hbonds with interfacial waters

No.	Contact Residues of Antigen	Secondary Structure	Solvent Accessibility	Number of Hbonds with Antibody	Number of Hydrophobic Interactions	Number of VdW Interactions	Number of Ionic Interactions	Number of Hbonds with Interfacial Waters
1	THR D -1	Coil	Exposed	2	5	11	0	0
2	SER D 0	Coil	Exposed	1	0	16	0	0
3	ASP D 2	Coil	Exposed	1	0	1	0	0
4	GLN D 61	Helix	Exposed	0	1	0	0	0
5	PHE D 64	Helix	Intermediate	0	2	2	0	0
6	THR D 86	Helix	Exposed	1	0	3	0	0
7	TYR D 89	Helix	Exposed	0	15	14	0	0
8	GLN D 90	Helix	Exposed	1	1	4	0	0
9	LEU D 92	Helix	Intermediate	0	7	2	0	0
10	ASN D 93	Helix	Exposed	1	5	11	0	0
11	GLU D 96	Helix	Exposed	0	0	3	0	0
12	ALA D 97	Helix	Intermediate	0	2	2	0	0
13	ILE D 100	Helix	Exposed	0	20	7	0	0
14	GLN D 101	Helix	Exposed	0	3	2	0	0


Interactions of contact residues of antigen		Structure of contact residues of antigen		Detailed contact residues of antigen

Number of interfacial waters = 0