pdb Hchain Lchain model antigen_chain antigen_type antigen_het_name antigen_name short_header date compound organism heavy_species light_species antigen_species authors resolution method r_free r_factor scfv engineered heavy_subclass light_subclass light_ctype affinity delta_g pmid 3ifn H L 0 P peptide NA amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 1.5 X-RAY DIFFRACTION 0.212 0.187 False True IGHV8 IGKV1 Kappa None None None 1ors B A 0 C protein NA potassium channel MEMBRANE PROTEIN 03/14/03 X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab AEROPYRUM PERNIX; MUS MUSCULUS mus musculus mus musculus aeropyrum pernix Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. 1.9 X-RAY DIFFRACTION 0.251 0.231 False False IGHV3 IGKV4 Kappa None None None 1g9m H L 0 G protein NA envelope glycoprotein gp120 Viral protein/Immune system 11/24/00 HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwong, P.D., Wyatt, R., Majeed, S., Robinson, J., Sweet, R.W., Sodroski, J., Hendrickson, W.A. 2.2 X-RAY DIFFRACTION 0.330 0.268 False True IGHV1 IGKV3 Kappa None None None 1mhp X Y 0 B protein NA integrin alpha 1, (residues 169-360) IMMUNE SYSTEM 08/20/02 Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Karpusas, M., Taylor, F., Ferrant, J., Weinreb, P., Garber, E. 2.8 X-RAY DIFFRACTION 0.272 0.213 False True IGHV3 IGKV1 Kappa None None None 4zto I M 0 Q peptide NA epitope of rabbit monoclonal antibody r53 IMMUNE SYSTEM 05/14/15 Fab/epitope complex structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R., Kong, X.-P. 2.3 X-RAY DIFFRACTION 0.223 0.167 False True IGHV1 IGKV1 Kappa None None None None None 3idm B A 0 C peptide NA gp41 mper peptide analog IMMUNE SYSTEM 07/21/09 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 Fab' fragment in complex with gp41 Peptide analog ELD(Nrg)WAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.236 0.229 False False IGHV2 IGKV1 Kappa None None None 2b0s H L 0 P peptide NA mn peptide of exterior membrane glycoprotein gp120 IMMMUNE SYSTEM 09/14/05 Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with MN peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Stanfield, R.L., Gorny, M.K., Zolla-Pazner, S., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.267 0.217 False False IGHV5 IGLV1 Lambda None None None 3lqa H L 0 G protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 02/08/10 Crystal structure of clade C gp120 in complex with sCD4 and 21c Fab HOMO SAPIENS; HIV-1 homo sapiens homo sapiens hiv-1 Diskin, R., Marcovecchio, P.M., Bjorkman, P.J. 3.4 X-RAY DIFFRACTION 0.322 0.234 False True IGHV1 IGLV1 Lambda 1.60E-06 -7.9 20357769 4hj0 C D 0 B protein NA gastric inhibitory polypeptide receptor IMMUNE SYSTEM 10/12/12 Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Madhurantakam, C., Ravn, P., Gruetter, M.G., Jackson, R.H. 3.0 X-RAY DIFFRACTION 0.311 0.255 False True IGHV1 IGLV1 Lambda None None None 4rwy H L 0 A protein NA hiv-1 yu2 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/08/14 Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC131 in complex with HIV-1 clade B YU2 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Luongo, T.S., Kwong, P.D. 2.128 X-RAY DIFFRACTION 0.254 0.219 False True unknown IGKV3 Kappa None None None None None 4ffv D C 0 B protein NA dipeptidyl peptidase 4 HYDROLASE/Immune System, INHIBITOR 06/01/12 Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Sudom, A., Walker, N.P., Min, X. 2.4 X-RAY DIFFRACTION 0.301 0.271 False False IGHV1 IGKV4 Kappa None None None 4bh7 B A 0 P peptide NA dodecapeptide antigen IMMUNE SYSTEM 03/30/13 CRYSTAL STRUCTURE OF GERMLINE ANTIBODY 36-65 IN COMPLEX WITH PEPTIDE PPYPAWHAPGNI MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.89 X-RAY DIFFRACTION 0.25419 0.22733 False False IGHV1 IGKV10 Kappa None None None None None 1zea H L 0 A peptide NA short synthetic d-amino acid peptide d2 IMMUNE SYSTEM 04/18/05 Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Scheerer, P., Krauss, N., Wessner, H., Scholz, C., Otte, L., Seifert, M., Kramer, A., Schneider-Mergener, J., Hoehne, W. 1.78 X-RAY DIFFRACTION 0.248 0.198 False False IGHV9 IGKV1 Kappa None None None 4g6a C D 0 B peptide NA e2 peptide IMMUNE SYSTEM 07/18/12 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Kong, L., Wilson, I.A., Law, M. 2.501 X-RAY DIFFRACTION 0.220 0.178 False True IGHV3 IGKV3 Kappa None None None 2or9 H L 0 P peptide NA synthetic epitope peptide of 9e10 IMMUNE SYSTEM 02/02/07 The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Krauss, N., Scheerer, P., Hoehne, W. 2.7 X-RAY DIFFRACTION 0.310 0.252 False False IGHV5 IGKV3 Kappa 5.00E-07 -8.6 18473392 4n0y H L 0 A peptide NA hcv e1 peptide IMMUNE SYSTEM 10/02/13 Structure of the Hepatitis C Envelope Glycoprotein E1 antigenic region 314-324 bound to the cross-neutralizing antibody IGH526 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Kong, L., Wilson, I.A. 1.749 X-RAY DIFFRACTION 0.210 0.179 False True IGHV1 IGLV1 Lambda None None None None None 2r0k H L 0 A protein NA hepatocyte growth factor activator HYDROLASE, IMMUNE SYSTEM 08/20/07 Protease domain of HGFA with inhibitor Fab58 HOMO SAPIENS homo sapiens Eigenbrot, C., Shia, S. 3.51 X-RAY DIFFRACTION 0.312 0.251 False True IGHV3 IGKV1 Kappa 6.00E-10 -12.57 18077410 4j6r H L 0 G protein NA envelope glycoprotein gp160 viral protein/immune system 02/11/13 Crystal structure of broadly and potently neutralizing antibody VRC23 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong P.D. 1.64 X-RAY DIFFRACTION 0.198 0.164 False True unknown IGKV3 Kappa None None None 3sob H L 0 B protein NA low-density lipoprotein receptor-related protein 6 PROTEIN BINDING/IMMUNE SYSTEM 06/30/11 The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, W., Bourhis, E., Tam, C., Zhang, Y., Rouge, L., Wu, Y., Franke, Y., Cochran, A.G. 1.9 X-RAY DIFFRACTION 0.212 0.174 False True IGHV3 IGKV1 Kappa None None None 3rvw D C 0 A protein NA peptidase 1 Hydrolase/IMMUNE SYSTEM 05/06/11 Crystal structure of Der p 1 complexed with Fab 4C1 MUS MUSCULUS; DERMATOPHAGOIDES PTERONYSSINUS mus musculus mus musculus dermatophagoides pteronyssinus Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W. 1.95 X-RAY DIFFRACTION 0.199 0.156 False True IGHV3 IGKV14 Kappa None None None 4xgz E F 0 e peptide NA unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa None None None None None 1ymh B A 0 E protein NA protein l IMMUNE SYSTEM 01/21/05 anti-HCV Fab 19D9D6 complexed with protein L (PpL) mutant A66W FINEGOLDIA MAGNA; MUS MUSCULUS mus musculus mus musculus finegoldia magna Granata, V., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 2.6 X-RAY DIFFRACTION 0.302 0.224 False False IGHV9 IGKV8 Kappa None None None 4wff E D 0 A protein NA potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a K+ bound nonconductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 2.5 X-RAY DIFFRACTION 0.245 0.213 False True IGHV1 IGKV4 Kappa None None None None None 4ut6 I M 0 B protein NA envelope glycoprotein e VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 B7 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 3.2 X-RAY DIFFRACTION 0.2500 0.2120 False True IGHV3 IGLV2 Lambda None None None None None 4iof C D 0 A protein NA insulin-degrading enzyme HYDROLASE 01/07/13 Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens McCord, L.A., Liang, W.G, Hoey, R., Dowdell, E., Koide, A., Koide, S., Tang, W.J. 3.353 X-RAY DIFFRACTION 0.280 0.232 False True IGHV3 IGKV1 Kappa None None None 3uc0 I M 0 B protein NA envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 10/25/11 Crystal structure of domain I of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 DENGUE VIRUS 4; PAN TROGLODYTES pan troglodytes pan troglodytes dengue virus 4 Cockburn, J.J.B., Stura, E.A., Navarro-Sanchez, M.E., Rey, F.A. 2.71 X-RAY DIFFRACTION 0.252 0.220 False True IGHV4 IGKV1 Kappa 1.30E-09 -12.6 22139356 4nzr H L 0 M protein NA protein m td IMMUNE SYSTEM/PROTEIN BINDING 12/12/13 Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-HIV antibody PGT135 Fab HOMO SAPIENS; MYCOPLASMA GENITALIUM homo sapiens homo sapiens mycoplasma genitalium Zhu, X., Wilson, I.A. 1.65 X-RAY DIFFRACTION 0.186 0.154 False True IGHV4 IGKV3 Kappa None None None None None 4lvn C B 0 A protein NA subtilisin-like serine protease hydrolase/inhibitor/immune system 07/26/13 Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Withers-Martinez, C., Blackman, M.J. 2.25 X-RAY DIFFRACTION 0.237 0.195 False False IGHV3 IGKV4 Kappa None None None None None 3b9k D C 0 F protein NA t-cell surface glycoprotein cd8 beta chain IMMUNE SYSTEM 11/05/07 Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB MUS MUSCULUS; RATTUS RATTUS rattus rattus rattus rattus mus musculus Shore, D., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.284 0.235 False False IGHV2 IGKV19 Kappa None None None 4ris H L 0 P peptide NA envelope glycoprotein Immune system 10/07/14 Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H.-X., Alam, S.M., Hwang, K.-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F. 2.3 X-RAY DIFFRACTION 0.246 0.161 False True IGHV5 IGLV6 Lambda None None None None None 3hpl A B 0 C protein NA voltage-gated potassium channel IMMUNE SYSTEM/metal TRANSPORT 06/04/09 KcsA E71H-F103A mutant in the closed state STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 3.2 X-RAY DIFFRACTION 0.269 0.220 False True IGHV1 IGKV5 Kappa None None None 3mj9 H L 0 A protein NA junctional adhesion molecule-like IMMUNE SYSTEM 04/12/10 Crystal structure of JAML in complex with the stimulatory antibody HL4E10 MUS MUSCULUS; CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius mus musculus Verdino, P., Wilson, I.A. 2.95 X-RAY DIFFRACTION 0.287 0.222 False False IGHV2 IGLV3 Lambda 7.69E-09 -11.06 21220118 3ghe H L 0 P peptide NA envelope glycoprotein IMMUNE SYSTEM 03/03/09 Crystal structure of anti-HIV-1 Fab 537-10D in complex with V3 peptide MN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.P., Burke, V.J. 2.4 X-RAY DIFFRACTION 0.241 0.187 False False IGHV3 IGLV2 Lambda 1.30E-06 -8.03 19913488 3ck0 H L 0 P peptide NA protein (8-mer; human angiotensin ii) IMMUNE SYSTEM 06/14/99 ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, COMPLEX WITH HUMAN ANGIOTENSIN II MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Pan, Y.H., Amzel, L.M. 3.0 X-RAY DIFFRACTION unknown 0.200 False False IGHV10 IGKV8 Kappa None None None 3hi1 H L 0 G protein NA glycoprotein 120 STRUCTURAL PROTEIN/Immune System 05/18/09 Structure of HIV-1 gp120 (core with V3) in Complex with CD4-Binding-Site Antibody F105 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 Kwon, Y.D., Chen, L., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z., Zhang, M.-Y., Arthos, J., Burton, D.R., Dimitrov, D., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.243 0.202 False False IGHV4 IGKV3 Kappa 1.12E-08 -10.84 19965434 4ojf H L 0 A peptide NA amyloid beta a4 protein Immune System 01/21/14 Humanised 3D6 Fab complexed to amyloid beta 1-8 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Miles, L.A., Crespi, G.A.N., Parker, M.W. 1.998 X-RAY DIFFRACTION 0.215 0.172 False True IGHV3 IGKV2 Kappa None None None None None 4xny H L 0 G protein NA envelope glycoprotein gp160,envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 01/16/15 Crystal structure of broadly and potently neutralizing antibody VRC08C in complex with HIV-1 clade A strain Q842.d12 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.217 0.182 False True unknown IGKV3 Kappa None None None None None 3se8 H L 0 G protein NA hiv-1 clade ae strain 93th057 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/10/11 Crystal structure of broadly and potently neutralizing antibody VRC03 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwong, P.D., Zhou, T. 1.895 X-RAY DIFFRACTION 0.233 0.187 False True IGHV1 IGKV3 Kappa None None None 1lk3 I M 0 B protein NA interleukin-10 IMMUNE SYSTEM 04/23/02 ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Josephson, K., Jones, B.C., Walter, L.J., DiGiacomo, R., Indelicato, S.R., Walter, M.R. 1.91 X-RAY DIFFRACTION 0.240 0.187 False False IGHV1 IGKV3 Kappa None None None 3lhp I M 0 T protein NA 4e10_d0_1isea_004_n (t93) IMMUNE SYSTEM 01/22/10 Crystal structure of HIV epitope-scaffold 4E10_D0_1ISEA_004_N 4E10 Fv complex HOMO SAPIENS; ARTIFICIAL GENE homo sapiens homo sapiens artificial gene Holmes, M.A. 2.7 X-RAY DIFFRACTION 0.335 0.243 False True IGHV1 IGKV3 Kappa 7.50E-12 -15.17 20826338 4m1d I M 0 Q peptide NA cyclic v3 arch peptide IMMUNE SYSTEM 08/02/13 Crystal structure of anti-HIV-1 Fab 447-52D in complex with V3 cyclic peptide MN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Killikelly, A., Kong, X.P. 1.8 X-RAY DIFFRACTION 0.216 0.186 False True IGHV3 IGLV1 Lambda None None None 2dqf B A 0 C protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 05/25/06 Crystal structure of hyhel-10 FV mutant (y33ay53a) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 2.5 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV5 Kappa None None None 4f15 H I 0 G protein NA hemagglutinin IMMUNE SYSTEM 05/06/12 Molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Lee, J.H., Park, Y.H., Khan, T.G., Lee, J.Y., Kang, S.H., Alam, I. 2.81 X-RAY DIFFRACTION 0.289 0.233 False False IGHV3 IGKV7 Kappa None None None 2xtj D B 0 A protein NA proprotein convertase subtilisin/kexin type 9 HYDROLASE/ANTIBODY 10/10/10 The crystal structure of PCSK9 in complex with 1D05 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Di Marco, S., Volpari, C., Carfi, A. 2.7 X-RAY DIFFRACTION 0.25944 0.19992 False True IGHV1 IGKV1D Kappa 4.40E-09 -11.39 20959675 3dvg B A 0 Y protein NA ubiquitin IMMUNE SYSTEM 07/18/08 Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G. 2.6 X-RAY DIFFRACTION 0.261 0.219 False True IGHV3 IGKV1 Kappa 8.70E-09 -10.99 18724939 2nz9 F E 0 B protein NA botulinum neurotoxin type a TOXIN/IMMUNE SYSTEM 11/22/06 Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2 CLOSTRIDIUM BOTULINUM clostridium botulinum Stevens, R.C., Arndt, J.W. 3.79 X-RAY DIFFRACTION 0.278 0.224 False False IGHV5 IGKV3 Kappa 6.80E-12 -15.12 17173035 3gbm I M 0 D protein NA hemagglutinin viral protein / immune system 02/20/09 Crystal Structure of Fab CR6261 in Complex with a H5N1 influenza virus hemagglutinin. INFLUENZA A VIRUS (A/VIET NAM/1203/2004(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) Ekiert, D.C., Elsliger, M.A., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.261 0.203 False True IGHV1 IGLV1 Lambda None None None 1fpt H L 0 P peptide NA fab fragment of an neutralizing antibody for type 1poliovirus COMPLEX (ANTIBODY/PV-1 FRAGMENT) 01/26/95 THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE HUMAN POLIOVIRUS 1; MUS MUSCULUS mus musculus mus musculus human poliovirus 1 Wien, M.W., Hogle, J.M. 3.0 X-RAY DIFFRACTION unknown 0.230 False True IGHV1 IGKV1 Kappa None None None 4p3c H L 0 M peptide NA matrix metalloproteinase-14 IMMUNE SYSTEM 03/06/14 MT1-MMP:Fab complex (Form I) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Rozenberg, H., Udi, Y., Sagi, I. 1.943 X-RAY DIFFRACTION 0.200 0.153 False True IGHV5 IGKV1 Kappa None None None None None 1wej H L 0 F protein NA cytochrome c COMPLEX (ANTIBODY/ELECTRON TRANSPORT) 03/26/98 IGG1 FAB FRAGMENT (OF E8 ANTIBODY) COMPLEXED WITH HORSE CYTOCHROME C AT 1.8 A RESOLUTION MUS MUSCULUS; EQUUS CABALLUS mus musculus mus musculus equus caballus Mylvaganam, S.E., Paterson, Y., Getzoff, E.D. 1.8 X-RAY DIFFRACTION 0.256 0.200 False False IGHV14 IGKV12 Kappa 1.58E-08 -10.63 7539913 4xnm B A 0 D protein NA hemagglutinin Viral protein/Immune system 01/15/15 Antibody Influenza H5 Complex HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Winarski, K.L., Spiler, B.W. 2.51 X-RAY DIFFRACTION 0.241 0.214 False True IGHV4 IGLV3 Lambda None None None None None 4gaj H L 0 P peptide NA genome polyprotein IMMUNE SYSTEM 07/25/12 Structure of the broadly neutralizing antibody AP33 in complex with its HCV epitope (E2 residues 411-424) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Potter, J.A., Owsianka, A., Taylor, G.L, Patel, A.H. 2.51 X-RAY DIFFRACTION 0.320 0.240 False False IGHV3 IGKV3 Kappa None None None 3ncy P S 0 B protein NA adic TRANSPORT PROTEIN 06/06/10 X-ray crystal structure of an arginine agmatine antiporter (AdiC) in complex with a Fab fragment SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; MUS MUSCULUS mus musculus mus musculus salmonella enterica subsp. enterica serovartyphimurium Fang, Y., Jayaram, H., Shane, T., Komalkova-Partensky, L., Wu, F., Williams, C., Xiong, Y., Miller, C. 3.2 X-RAY DIFFRACTION 0.312 0.282 False True IGHV1 IGKV4 Kappa None None None 3bsz H L 0 F protein NA plasma retinol-binding protein TRANSPORT PROTEIN/IMMUNE SYSTEM 12/27/07 Crystal structure of the transthyretin-retinol binding protein-Fab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zanotti, G., Cendron, L., Gliubich, F., Folli, C., Berni, R. 3.38 X-RAY DIFFRACTION 0.312 0.239 False True IGHV1 IGKV3 Kappa None None None 3mlw I M 0 Q peptide NA hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 1006-15D in complex with an MN V3 peptide HIV-1 M:B_MN; HOMO SAPIENS homo sapiens homo sapiens hiv-1 m Kong, X.-P. 2.7 X-RAY DIFFRACTION 0.291 0.214 False False IGHV5 IGLV1 Lambda None None None 5c8j A B 0 I protein NA protein mj0480 MEMBRANE PROTEIN 06/25/15 A YidC-like protein in the archaeal plasma membrane HOMO SAPIENS; METHANOCALDOCOCCUS JANNASCHII (STRAIN ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) homo sapiens homo sapiens methanocaldococcus jannaschii (strain atcc43067 / dsm 2661 / jal-1 / jcm 10045 / nbrc 100440) Borowska, M.T., Dominik, P.K., Anghel, S.A., Kossiakoff, A.A., Keenan, R.J. 3.502 X-RAY DIFFRACTION 0.302 0.253 False True IGHV3 IGKV1 Kappa None None None None None 4hpo H L 0 P peptide NA envelope glycoprotein gp160 Immune System/Viral Protein 10/24/12 Crystal structure of RV144-elicited antibody CH58 in complex with V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 McLellan, J.S., Gorman, J., Haynes, B.F., Kwong, P.D. 1.694 X-RAY DIFFRACTION 0.211 0.185 False True IGHV5 IGLV6 Lambda None None None 4ers H L 0 A protein NA glucagon receptor IMMUNE SYSTEM 04/20/12 A Molecular Basis for Negative Regulation of the Glucagon Receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murray, J.M., Koth, C.M., Mukund, S. 2.637 X-RAY DIFFRACTION 0.279 0.231 False True IGHV3 IGKV1 Kappa None None None 4j4p H L 0 A protein NA ig epsilon chain c region IMMUNE SYSTEM 02/07/13 The complex of human IgE-Fc with two bound Fab fragments HOMO SAPIENS homo sapiens homo sapiens homo sapiens Drinkwater, N., Sutton, B.J. 2.91 X-RAY DIFFRACTION 0.284 0.236 False True IGHV6 IGLV1 Lambda None None None None None 3kr3 H L 0 D protein NA insulin-like growth factor ii IMMUNE SYSTEM 11/17/09 Crystal structure of IGF-II antibody complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Peat, T.S., Newman, J., Adams, T.E. 2.2 X-RAY DIFFRACTION 0.251 0.199 False True IGHV3 IGKV1 Kappa 4.90E-11 -14.06 20515953 4dqo H L 0 C protein NA 1fd6-v1v2 scaffold zm109 hiv-1 strain IMMUNE SYSTEM 02/16/12 Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., McLellan, J.S., Kwong, P.D. 2.438 X-RAY DIFFRACTION 0.230 0.201 False True IGHV3 IGLV2 Lambda None None None 4yk4 C B 0 A protein NA hemagglutinin Viral protein/Immune system 03/03/15 Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Schmidt, A.G., Harrison, S.C. 2.8 X-RAY DIFFRACTION 0.260 0.220 False True IGHV4 IGKV1 Kappa None None None None None 1qfw I M 0 B protein NA gonadotrophin beta subunit IMMUNE SYSTEM 04/15/99 TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Tegoni, M., Spinelli, S., Cambillau, C. 3.5 X-RAY DIFFRACTION 0.310 0.260 False True IGHV5 IGKV6 Kappa None None None 4kuc F E 0 I protein NA ricin HYDROLASE/IMMUNE SYSTEM 05/21/13 Crystal structure of ricin-A chain in complex with the antibody 6C2 RICINUS COMMUNIS; MUS MUSCULUS mus musculus mus musculus ricinus communis Zhu, Y., Li, X., Teng, M. 2.787 X-RAY DIFFRACTION 0.289 0.238 False True IGHV1 IGKV3 Kappa None None None 3ztj K L 0 F protein NA hemagglutinin ha2 chain IMMUNE SYSTEM/VIRAL PROTEIN 07/08/11 Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin. HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Voss, J.E., Vachieri, S.G., Gamblin, S.J., Collins, P.J., Haire, L.F., Skehel, J.J. 3.41 X-RAY DIFFRACTION 0.28434 0.23410 False True IGHV3 IGKV4 Kappa None None None 3v4u H L 0 P peptide NA h-2 class i histocompatibility antigen, l-d alpha chain IMMUNE SYSTEM 12/15/11 Structure of a monoclonal antibody complexed with its MHC-I antigen MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K. 1.64 X-RAY DIFFRACTION 0.251 0.213 False False IGHV5 IGKV1 Kappa None None None 2x7l C D 0 P protein NA hiv rev IMMUNE SYSTEM 03/01/10 Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element UNCLASSIFIED; HUMAN IMMUNODEFICIENCY VIRUS TYPE 3 unclassified unclassified human immunodeficiency virus type 3 DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M. 3.17 X-RAY DIFFRACTION 0.2500 0.2337 False True IGHV1 IGKV1 Kappa None None None 4wht G H 0 g peptide NA unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa None None None None None 3mlv H L 0 P peptide NA hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with an NOF V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.48 X-RAY DIFFRACTION 0.342 0.233 False False IGHV5 IGLV3 Lambda None None None 1kc5 H L 0 P peptide NA ps1 peptide IMMUNE SYSTEM 11/07/01 CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Nair, D.T., Singh, K., Siddiqui, Z., Nayak, B.P., Rao, K.V., Salunke, D.M. 2.5 X-RAY DIFFRACTION 0.270 0.195 False False IGHV3 IGKV6 Kappa None None None 2otu H G 0 S peptide NA peptide antigen IMMUNE SYSTEM 02/09/07 Crystal structure of Fv polyglutamine complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Li, P. 1.68 X-RAY DIFFRACTION 0.214 0.200 False True IGHV5 IGLV3 Lambda None None None 2vxs I M 0 A protein NA interleukin-17a CYTOKINE 07/09/08 Structure of IL-17A in complex with a potent, fully human neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gerhardt, S., Hargreaves, D., Pauptit, R.A., Davies, R.A., Russell, C., Welsh, F., Tuske, S.J., Coales, S.J., Hamuro, Y., Needham, M.R.C., Langham, C., Barker, W., Bell, P., Aziz, A., Smith, M.J., Dawson, S., Abbott, W.M. 2.63 X-RAY DIFFRACTION 0.264 0.213 False True IGHV3 IGLV6 Lambda 2.10E-09 -11.83 19835883 4xwg H L 0 A protein NA phosphatidylcholine-sterol acyltransferase Hydrolase/Immune system 01/28/15 Crystal Structure of LCAT (C31Y) in complex with Fab1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T. 2.65 X-RAY DIFFRACTION 0.251 0.176 False True IGHV3 IGLV3 Lambda None None None None None 1a3r H L 0 P peptide NA human rhinovirus capsid protein vp2 VIRAL PROTEIN/IMMUNE SYSTEM 01/23/98 FAB FRAGMENT (ANTIBODY 8F5) COMPLEXED WITH PEPTIDE FROM HUMAN RHINOVIRUS (SEROTYPE 2) VIRAL CAPSID PROTEIN VP2 (RESIDUES 156-170) MUS MUSCULUS; HUMAN RHINOVIRUS 2 mus musculus mus musculus human rhinovirus 2 Tormo, J., Blaas, D., Fita, I. 2.1 X-RAY DIFFRACTION unknown 0.171 False False IGHV14 IGKV8 Kappa None None None 2uud J K 0 T peptide NA nq10-1.12 anti-phox antibody IMMUNE SYSTEM 03/02/07 Crystal structure of the TEPC15-Vk45.1 anti-2-phenyl-5-oxazolone NQ10- 1.12 scFv in complex with the hapten MUS MUSCULUS mus musculus mus musculus mus musculus Scotti, C., Gherardi, E. 2.9 X-RAY DIFFRACTION 0.297 0.228 False True IGHV7 IGKV1 Kappa None None None 3b2v H L 0 A protein NA epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 3.3 X-RAY DIFFRACTION 0.367 0.282 False True IGHV4 IGKV3 Kappa 3.30E-09 -11.56 18275813 3t3p H L 0 A protein NA integrin alpha-iib CELL ADHESION 07/25/11 A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, J., Zhu, J., Springer, T.A. 2.2 X-RAY DIFFRACTION 0.220 0.189 False True IGHV14 IGKV14 Kappa None None None 4jo2 H L 0 P peptide NA gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/16/13 Crystal structure of rabbit mAb R56 Fab in complex with V3 crown of HIV-1 Consensus A gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R.M., Kong, X.P. 2.5 X-RAY DIFFRACTION 0.265 0.190 False True IGHV1 IGKV1 Kappa None None None 1fsk I H 0 G protein NA major pollen allergen bet v 1-a IMMUNE SYSTEM 09/11/00 COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 BETULA PENDULA; MUS MUSCULUS mus musculus mus musculus betula pendula Mirza, O., Henriksen, A., Ipsen, H., Larsen, J., Wissenbach, M., Spangfort, M., Gajhede, M. 2.9 X-RAY DIFFRACTION 0.285 0.253 False True IGHV1 IGKV6 Kappa None None None 3wih I M 0 B protein NA roundabout homolog 1 IMMUNE SYSTEM 09/12/13 Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nakayama, T., Mizohata, E., Yamashita, T., Nagatoishi, M., Iwanari, H., Mochizuki, Y., Kado, Y., Yokota, Y., Sato, R., Tsumoto, K., Fujitani, H., Kodama, T., Hamakubo, T., Inoue, T. 1.701 X-RAY DIFFRACTION 0.236 0.189 False False IGHV1 IGKV10 Kappa None None None None None 1hez B A 0 E protein NA protein l ANTIBODY 11/27/00 antibody-antigen complex HOMO SAPIENS; FINEGOLDIA MAGNA homo sapiens homo sapiens finegoldia magna Graille, M., Stura, E.A., Housden, N.G., Bottomley, S.P., Taussig, M.J., Sutton, B.J., Gore, M.G., Charbonnier, JB. 2.7 X-RAY DIFFRACTION 0.278 0.215 False False IGHV3 IGKV1 Kappa 1.45E-07 -9.32 11587642 1za3 H L 0 R protein NA tumor necrosis factor receptor superfamily member 10b IMMUNE SYSTEM/SIGNALING PROTEIN 04/05/05 The crystal structure of the YSd1 Fab bound to DR5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Fellouse, F.A., Li, B., Compaan, D.M., Peden, A.A., Hymowitz, S.G., Sidhu, S.S. 3.35 X-RAY DIFFRACTION 0.280 0.224 False True IGHV3 IGKV1 Kappa 3.40E-08 -10.18 15854651 2xqb H L 0 A protein NA interleukin 15 IMMUNE SYSTEM 09/01/10 Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lowe, D.C., Gerhardt, S., Ward, A., Hargreaves, D., Anderson, M., StGallay, S., Vousden, K., Ferraro, F., Pauptit, R.A., Cochrane, D., Pattison, D.V., Buchanan, C., Popovic, B., Finch, D.K., Wilkinson, T., Sleeman, M., Vaughan, T.J., Cruwys, S., Mallinder, P.R. 2.6 X-RAY DIFFRACTION 0.31811 0.24441 False True IGHV1 IGLV1 Lambda 5.20E-11 -14.02 21167836 1v7m I M 0 X protein NA thrombopoietin IMMUNE SYSTEM/CYTOKINE 12/18/03 Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R. 2.51 X-RAY DIFFRACTION 0.316 0.228 False True IGHV6 IGKV4 Kappa None None None 3qnz B A 0 C peptide NA peptide from tubulin beta chain IMMUNE SYSTEM 02/09/11 Orthorhombic form of IgG1 Fab fragment (in complex with antigenic tubulin peptide) sharing same Fv as IgA HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Trajtenberg, F., Correa, A., Buschiazzo, A. 2.2 X-RAY DIFFRACTION 0.235 0.196 False False IGHV3 IGKV2 Kappa None None None 1nl0 H L 0 G peptide NA factor ix IMMUNE SYSTEM 01/06/03 Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Huang, M., Furie, B.C., Furie, B. 2.2 X-RAY DIFFRACTION 0.270 0.233 False True IGHV3 IGLV1 Lambda None None None 4k9e H L 0 C protein NA mast/stem cell growth factor receptor kit IMMUNE SYSTEM 04/19/13 Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J. 2.7 X-RAY DIFFRACTION 0.282 0.247 False True IGHV3 IGKV1 Kappa None None None None None 3fmg H L 0 A protein NA glycoprotein vp7 IMMUNE SYSTEM 12/22/08 Structure of rotavirus outer capsid protein VP7 trimer in complex with a neutralizing Fab SIMIAN ROTAVIRUS; MUS MUSCULUS mus musculus mus musculus simian rotavirus Aoki, S.T., Settembre, E.C., Trask, S.D., Greenberg, H.B., Harrison, S.C., Dormitzer, P.R. 3.4 X-RAY DIFFRACTION 0.238 0.224 False False IGHV1 IGKV12 Kappa None None None 4k3j H L 0 B protein NA hepatocyte growth factor beta chain Transferase/Immune System/Growth Factor 04/10/13 Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Ma, X., Starovasnik, M.A. 2.8 X-RAY DIFFRACTION 0.253 0.211 False True IGHV3 IGKV1 Kappa None None None 3w9e A B 0 C protein NA envelope glycoprotein d VIRAL PROTEIN/IMMUNE SYSTEM 04/03/13 Structure of Human Monoclonal Antibody E317 Fab Complex with HSV-2 gD HOMO SAPIENS; HUMAN HERPESVIRUS 2 homo sapiens homo sapiens human herpesvirus 2 Lee, C.C., Lin, L.L., Wang, A.H.J. 2.3 X-RAY DIFFRACTION 0.255 0.203 False True IGHV1 IGKV3 Kappa None None None 3u9p K M 0 C protein NA neutrophil gelatinase-associated lipocalin IMMUNE SYSTEM 10/19/11 Crystal Structure of Murine Siderocalin in Complex with an Fab Fragment MUS MUSCULUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Correnti, C., Strong, R.K. 2.8 X-RAY DIFFRACTION 0.292 0.219 False True IGHV2 IGKV19 Kappa None None None 4hs6 H L 0 Y peptide NA e2-peptide IMMUNE SYSTEM 10/29/12 Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody MRCT10.v362 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Eigenbrot, C., Ultsch, M. 1.53 X-RAY DIFFRACTION 0.200 0.175 False True IGHV4 IGKV1 Kappa None None None 4tnw I O 0 D protein NA avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False IGHV1 IGLV1 Lambda None None None None None 1egj H L 0 A protein NA cytokine receptor common beta chain precursor IMMUNE SYSTEM 02/15/00 DOMAIN 4 OF THE BETA COMMON CHAIN IN COMPLEX WITH AN ANTIBODY HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rossjohn, J., McKinstry, W.J., Woodcock, J.M., McClure, B.J., Hercus, T.R., Parker, M.W., Lopez, A.F., Bagley, C.J. 2.8 X-RAY DIFFRACTION 0.288 0.228 False False IGHV1 IGKV3 Kappa None None None 1eo8 H L 0 A protein NA hemagglutinin (ha1 chain) Viral protein/Immune system 03/22/00 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Fleury, D., Gigant, B., Daniels, R.S., Skehel, J.J., Knossow, M., Bizebard, T. 2.8 X-RAY DIFFRACTION 0.298 0.196 False False IGHV1 IGKV4 Kappa 8.90E-09 -10.87 10899782 1bj1 K J 0 V protein NA vascular endothelial growth factor COMPLEX (ANTIBODY/ANTIGEN) 06/30/98 VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Muller, Y.A., Christinger, H.W., De Vos, A.M. 2.4 X-RAY DIFFRACTION 0.266 0.196 False True IGHV7 IGKV1 Kappa 3.40E-09 -11.55 9753694 1fe8 H L 0 A protein NA von willebrand factor IMMUNE SYSTEM 07/21/00 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Bouma, B., Huizinga, E.G., Schiphorst, M.E., Sixma, J.J., Kroon, J., Gros, P. 2.03 X-RAY DIFFRACTION 0.264 0.227 False False IGHV2 IGKV10 Kappa None None None 4o58 H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/3/1975 (H3N2) influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 2.7501 X-RAY DIFFRACTION 0.224 0.177 False True IGHV1 IGLV1 Lambda None None None None None 3h0t B A 0 C peptide NA hepcidin IMMUNE SYSTEM/Antimicrobial Protein 04/10/09 Hepcidin-Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Syed, R., Li, V. 1.89 X-RAY DIFFRACTION 0.251 0.202 False True IGHV6 IGLV6 Lambda None None None 4jfx H L 0 P peptide NA phosphopeptide immune system 02/28/13 protein complex3 ESCHERICHIA COLI; SYNTHETIC CONSTRUCT Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 1.95 X-RAY DIFFRACTION 0.202 0.163 False True IGHV3 IGKV3 Kappa None None None 4l5f H L 0 E protein NA envelope protein VIRAL PROTEIN, IMMUNE SYSTEM 06/11/13 Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Edeling, M.A., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.45 X-RAY DIFFRACTION 0.239 0.190 False False IGHV1 IGKV17 Kappa None None None None None 4g80 E F 0 T protein NA voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (WT, 3.8 A) HOMO SAPIENS; CIONA INTESTINALIS homo sapiens homo sapiens ciona intestinalis Li, Q. 3.58 X-RAY DIFFRACTION 0.292 0.248 False True IGHV3 IGKV1 Kappa None None None None None 4ydv B A 0 Q peptide NA hiv gp41 peptide gp41(596-606) IMMUNE SYSTEM 02/23/15 STRUCTURE OF THE ANTIBODY 7B2 THAT CAPTURES HIV-1 VIRIONS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Nicely, N.I., Pemble IV, C.W. 2.7 X-RAY DIFFRACTION 0.223 0.189 False True IGHV3 IGKV4 Kappa None None None None None 3pjs B A 0 M protein NA voltage-gated potassium channel TRANSPORT PROTEIN 11/10/10 Mechanism of Activation Gating in the Full-Length KcsA K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Uysal, S., Cuello, L.G., Kossiakoff, A., Perozo, E. 3.8 X-RAY DIFFRACTION 0.332 0.281 False True IGHV3 IGKV1 Kappa None None None 4ye4 H L 0 G protein NA ht593.1 gp120 Viral protein/Immune system 02/23/15 Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Kwong, P.D., Chen, L., Zhou, T. 2.72 X-RAY DIFFRACTION 0.242 0.187 False True unknown unknown unknown None None None None None 4ht1 H L 0 T protein NA tumor necrosis factor ligand superfamily member 12 IMMUNE SYSTEM 10/31/12 Human TWEAK in complex with the Fab fragment of a neutralizing antibody HOMO SAPIENS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Lammens, A. 2.498 X-RAY DIFFRACTION 0.211 0.183 False False IGHV1 IGKV1 Kappa None None None 3lex A B 0 C peptide NA envelope glycoprotein gp41 IMMUNE SYSTEM 01/15/10 2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D. 1.97 X-RAY DIFFRACTION 0.198 0.165 False False IGHV3 IGKV1 Kappa None None None 3gjf M K 0 D protein NA hla class i histocompatibility antigen, a-2alpha chain IMMUNE SYSTEM 03/08/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E., Kleber, S., Stenner-Liewen, F., Bauer, S., McMichael, A., Knuth, A., Abken, H., Hombach, A.A., Cerundolo, V., Jones, E.Y., Renner, C. 1.9 X-RAY DIFFRACTION 0.251 0.202 False True IGHV3 IGLV2 Lambda 6.30E-08 -9.82 19307587 1bgx H L 0 T protein NA taq dna polymerase COMPLEX (POLYMERASE/INHIBITOR) 06/02/98 TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB THERMUS AQUATICUS; MUS MUSCULUS mus musculus mus musculus thermus aquaticus Murali, R., Sharkey, D.J., Daiss, J.L., Krishna Murthy, H.M. 2.3 X-RAY DIFFRACTION 0.253 0.189 False True IGHV3 IGKV4 Kappa None None None 1sm3 H L 0 P peptide NA peptide epitope COMPLEX (ANTIBODY/PEPTIDE EPITOPE) 12/23/97 CRYSTAL STRUCTURE OF THE TUMOR SPECIFIC ANTIBODY SM3 COMPLEX WITH ITS PEPTIDE EPITOPE MUS MUSCULUS mus musculus mus musculus Dokurno, P., Bates, P.A., Band, H.A., Stewart, L.M.D., Lally, J.M., Burchell, J.M., Taylor-Papadimitriou, J., Sternberg, M.J.E., Snary, D., Freemont, P.S. 1.95 X-RAY DIFFRACTION 0.283 0.213 False False IGHV6 IGLV1 Lambda None None None 4dtg H L 0 K protein NA tissue factor pathway inhibitor BLOOD CLOTTING INHIBITOR/IMMUNE SYSTEM 02/21/12 Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model HOMO SAPIENS homo sapiens homo sapiens homo sapiens Svensson, L.A., Breinholt, J., Krogh, B.O., Hilden, I. 1.8 X-RAY DIFFRACTION 0.236 0.196 False True IGHV3 IGKV2 Kappa None None None 4f2m C D 0 F protein NA spike protein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/12 Crystal structure of a TGEV coronavirus Spike fragment in complex with the TGEV neutralizing monoclonal antibody 1AF10 TGEV VIRULENT PURDUE; MUS MUSCULUS mus musculus mus musculus tgev virulent purdue Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M. 3.0 X-RAY DIFFRACTION 0.251 0.216 False True IGHV1 IGKV5 Kappa None None None 2xwt A B 0 C protein NA thyrotropin receptor SIGNALING PROTEIN/IMMUNE SYSTEM 11/05/10 Crystal structure of the TSH receptor in complex with a blocking type TSHR autoantibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sanders, J., Sanders, P., Young, S., Kabelis, K., Baker, S., Sullivan, A., Evans, M., Clark, J., Wilmot, J., Hu, X., Roberts, E., Powell, M., Nunez Miguel, R., Furmaniak, J., Rees Smith, B. 1.9 X-RAY DIFFRACTION 0.22674 0.17691 False True IGHV5 IGLV1 Lambda None None None 4u1g B C 0 A protein NA reticulocyte binding protein 5 IMMUNE SYSTEM 07/15/14 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody QA1 PLASMODIUM FALCIPARUM; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus plasmodium falciparum Wright, K.E., Hjerrild, K.A., Bartlett, J., Douglas, A.D., Jin, J., Brown, R.E., Ashfield, R., Clemmensen, S.B., de Jongh, W.A., Draper, S.J., Higgins, M.K. 3.1 X-RAY DIFFRACTION 0.281 0.236 False True IGHV5 IGKV3 Kappa None None None None None 4hfu H L 0 A protein NA hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 10/05/12 Crystal structure of Fab 8M2 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.106 X-RAY DIFFRACTION 0.251 0.193 False True IGHV1 IGKV3 Kappa None None None 4rrp L F 0 R protein NA antigen asf1p IMMUNE SYSTEM 11/06/14 Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Kuzin, A., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Oconnell, P.T., Maglaqui, M., Bailey, L., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG) 2.79 X-RAY DIFFRACTION 0.253 0.183 False True IGHV3 IGKV1 Kappa None None None None None 2vir B A 0 C protein NA hemagglutinin COMPLEX (HEMAGGLUTININ/IMMUNOGLOBULIN) 12/22/97 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Bizebard, T., Fleury, D., Gigant, B., Wharton, S.A., Skehel, J.J., Knossow, M. 3.25 X-RAY DIFFRACTION 0.249 0.198 False False IGHV2 IGLV1 Lambda 1.00E-09 -12.27 9461077 3o45 A B 0 C peptide NA fusion glycoprotein f1 IMMUNE SYSTEM/VIRAL PROTEIN 07/26/10 Crystal Structure of 101F Fab Bound to 17-mer Peptide Epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus McLellan, J.S., Chen, M., Chang, J.S., Yang, Y., Kim, A., Graham, B.S., Kwong, P.D. 2.872 X-RAY DIFFRACTION 0.254 0.200 False True IGHV8 IGKV3 Kappa None None None 1xiw D C 0 A protein NA t-cell surface glycoprotein cd3 epsilon chain membrane protein/Immune System 09/22/04 Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Arnett, K.L., Harrison, S.C., Wiley, D.C. 1.9 X-RAY DIFFRACTION 0.241 0.204 False True IGHV1 IGKV10 Kappa None None None 3lzf H L 0 A protein NA hemagglutinin, ha1 subunit VIRAL PROTEIN/IMMUNE SYSTEM 03/01/10 Crystal Structure of Fab 2D1 in Complex with the 1918 Influenza Virus Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.259 0.230 False True IGHV2 IGLV1 Lambda None None None 4rav A B 0 E peptide NA huntingtin IMMUNE SYSTEM/Apoptosis 09/11/14 Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens De Genst, E., Chirgadze, D.Y., Dobson, C.M. 2.5 X-RAY DIFFRACTION 0.226 0.180 False True IGHV3 IGLV2 Lambda None None None None None 4i2x B A 0 E protein NA signal-regulatory protein gamma IMMUNE SYSTEM 11/23/12 Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nettleship, J.E., Ren, J., Stuart, D.I., Owens, R.J., Oxford Protein Production Facility (OPPF) 2.48 X-RAY DIFFRACTION 0.260 0.196 False False IGHV1 IGKV6 Kappa None None None None None 1ifh H L 0 P peptide NA influenza hemagglutinin ha1 (strain x47)(residues 101-107) IMMUNOGLOBULIN 05/06/93 A DETAILED ANALYSIS OF THE FREE AND BOUND CONFORMATION OF AN ANTIBODY: X-RAY STRUCTURES OF ANTI-PEPTIDE FAB 17(SLASH)9 AND THREE DIFFERENT FAB-PEPTIDE COMPLEXES MUS MUSCULUS mus musculus mus musculus Schulze-Gahmen, U., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.170 False True IGHV5 IGKV8 Kappa None None None 1jrh H L 0 I protein NA interferon-gamma receptor alpha chain COMPLEX (ANTIBODY/ANTIGEN) 09/23/97 COMPLEX (ANTIBODY/ANTIGEN) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Winkler, F.K., Sogabe, S. 2.8 X-RAY DIFFRACTION 0.314 0.246 False False IGHV8 IGKV13 Kappa 1.42E-08 -10.7 9367779 4xtr C D 0 B protein NA atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/23/15 Structure of Get3 bound to the transmembrane domain of Pep12 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (strain atcc 204508 /s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.05 X-RAY DIFFRACTION 0.216 0.187 False True IGHV3 IGKV1 Kappa None None None None None 1s78 D C 0 A protein NA receptor protein-tyrosine kinase erbb-2 TRANSFERASE 01/29/04 Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Franklin, M.C., Carey, K.D., Vajdos, F.F., Leahy, D.J., de Vos, A.M., Sliwkowski, M.X. 3.25 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV1 Kappa None None None 3eoa B A 0 J protein NA integrin alpha-l IMMUNE SYSTEM/CELL ADHESION 09/26/08 Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, S., Ding, J. 2.8 X-RAY DIFFRACTION 0.264 0.225 False True IGHV3 IGKV1 Kappa 2.20E-09 -11.8 19258452 1mpa H L 0 P peptide NA pora p1.16 peptide fluorescein conjugate COMPLEX (IMMUNOGLOBULIN/PEPTIDE) 02/26/97 BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS MUS MUSCULUS mus musculus mus musculus Van Den Elsen, J.M.H., Herron, J.N., Kroon, J., Gros, P. 2.6 X-RAY DIFFRACTION 0.309 0.194 False True IGHV1 IGKV1 Kappa None None None 3liz H L 0 A protein NA aspartic protease bla g 2 hydrolase/immune system 01/25/10 crystal structure of bla g 2 complexed with Fab 4C3 BLATTELLA GERMANICA; MUS MUSCULUS mus musculus mus musculus blattella germanica Li, M., Gustchina, A., Glesner, J., Wunschmann, S., Pomes, A., Wlodawer, A. 1.8 X-RAY DIFFRACTION 0.202 0.177 False False IGHV5 IGKV14 Kappa None None None 2hfg H L 0 R peptide NA tumor necrosis factor receptor superfamily member 13c IMMUNE SYSTEM 06/23/06 Crystal structure of hBR3 bound to CB3s-Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G. 2.61 X-RAY DIFFRACTION 0.252 0.195 False True IGHV3 IGKV1 Kappa 6.00E-10 -12.57 16840730 3o6l H L 0 C peptide NA protein tat 15-mer peptide IMMUNE SYSTEM 07/29/10 Anti-Tat HIV 11H6H1 Fab' complexed with a 15-mer Tat peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Serriere, J., Gouet, P., Guillon, C. 2.1 X-RAY DIFFRACTION 0.227 0.186 False False IGHV5 IGKV1 Kappa 3.10E-08 -9.93 21035463 3ggw B A 0 E peptide NA peptide b1 IMMUNE SYSTEM 03/02/09 Crystal Structure of FAB F22-4 in complex with a Carbohydrate-mimetic peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Saul, F.A., Vulliez-Le Normand, B., Bentley, G.A. 1.7 X-RAY DIFFRACTION 0.245 0.197 False False IGHV6 IGKV2 Kappa 2.90E-06 -7.55 19328810 3u4e A B 0 J protein NA v1v2 region of hiv-1 on 1fd6 scaffold IMMUNE SYSTEM 10/07/11 Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain CAP45 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., McLellan, J., Pancera, M., Kwong, P.D. 2.185 X-RAY DIFFRACTION 0.234 0.182 False True IGHV3 IGLV2 Lambda None None None 4cni H L 0 C protein NA interleukin-6 01/22/14 Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A. 2.2 X-RAY DIFFRACTION 0.21549 0.17608 False True IGHV3 IGKV1 Kappa None None None None None 4y5x J K 0 L protein NA erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 3.15 X-RAY DIFFRACTION 0.241 0.201 False True IGHV3 IGLV1 Lambda None None None None None 3raj H L 0 A protein NA adp-ribosyl cyclase 1 HYDROLASE/IMMUNE SYSTEM 03/28/11 Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhang, H., Lee, H.C., Hao, Q. 3.044 X-RAY DIFFRACTION 0.275 0.205 False True IGHV2 IGKV13 Kappa None None None 4z5r B A 0 N protein NA interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa None None None None None 4dag H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 01/12/12 Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site HUMAN METAPNEUMOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human metapneumovirus Jardetzky, T.S., Wen, X. 3.3904 X-RAY DIFFRACTION 0.289 0.260 False True IGHV3 IGLV3 Lambda None None None 4edw H L 0 V protein NA beta-nerve growth factor immune system 03/27/12 Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Ultsch, M. 2.48 X-RAY DIFFRACTION 0.249 0.200 False True IGHV4 IGKV1 Kappa None None None None None 3mac H L 0 A protein NA transmembrane glycoprotein IMMUNE SYSTEM 03/23/10 crystal structure of GP41-derived protein complexed with fab 8062 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Li, M., Gustchina, E., Louis, J., Gustchina, A., Wlodawer, A., Clore, M. 2.5 X-RAY DIFFRACTION 0.264 0.200 False True IGHV1 IGLV3 Lambda 2.00E-07 -9.23 21085615 4dw2 H L 0 U protein NA urokinase-type plasminogen activator HYDROLASE/IMMUNE SYSTEM 02/24/12 The crystal structure of uPA in complex with the Fab fragment of mAb-112 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M. 2.97 X-RAY DIFFRACTION 0.300 0.240 False False IGHV5 IGKV4 Kappa None None None 1fbi H L 0 X protein NA guinea fowl lysozyme COMPLEX (ANTIBODY/ANTIGEN) 01/19/95 CRYSTAL STRUCTURE OF A CROSS-REACTION COMPLEX BETWEEN FAB F9.13.7 AND GUINEA-FOWL LYSOZYME MUS MUSCULUS; NUMIDA MELEAGRIS mus musculus mus musculus numida meleagris Lescar, J., Alzari, P.M. 3.0 X-RAY DIFFRACTION unknown 0.190 False True IGHV1 IGKV10 Kappa None None None 3zkm H L 0 A protein NA beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 01/23/13 BACE2 FAB COMPLEX HOMO SAPIENS; MUS MUSCULUS homo sapiens mus musculus homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 1.85 X-RAY DIFFRACTION 0.24545 0.21077 False True IGHV2 IGKV3 Kappa None None None 4mwf H L 0 C protein NA envelope glycoprotein e2 IMMUNE SYSTEM 09/24/13 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core bound to broadly neutralizing antibody AR3C HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Kong, L., Wilson, I.A., Law, M. 2.645 X-RAY DIFFRACTION 0.270 0.231 False True IGHV1 IGKV3 Kappa None None None None None 1afv K M 0 B protein NA human immunodeficiency virus type 1 capsidprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/14/97 HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Momany, C., Kovari, L.C., Prongay, A.J., Keller, W., Gitti, R.K., Lee, B.M., Gorbalenya, A.E., Tong, L., Mcclure, J., Ehrlich, L.S., Summers, M.F., Carter, C., Rossmann, M.G. 3.7 X-RAY DIFFRACTION 0.324 0.217 False False IGHV1 IGKV3 Kappa None None None 3bn9 F E 0 A protein NA membrane-type serine protease 1 HYDROLASE 12/13/07 Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Farady, C.J., Schneider, E.L., Egea, P.F., Goetz, D.H., Craik, C.S. 2.173 X-RAY DIFFRACTION 0.267 0.223 False True IGHV3 IGKV1 Kappa None None None 1z3g I M 0 B protein NA ookinete surface protein pvs25 IMMUNE SYSTEM/CELL ADHESION 03/12/05 Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8 MUS MUSCULUS; PLASMODIUM VIVAX SAI-1 mus musculus mus musculus plasmodium vivax sai-1 Saxena, A.K., Singh, K., Su, H.P., Klein, M.M., Stowers, A.W., Saul, A.J., Long, C.A., Garboczi, D.N. 3.3 X-RAY DIFFRACTION 0.327 0.272 False True IGHV1 IGKV4 Kappa None None None 4xp4 H L 0 A protein NA dopamine transporter transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter in complex with cocaine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Aravind, P., Wang, K., Gouaux, E. 2.8 X-RAY DIFFRACTION 0.266 0.236 False True IGHV5 IGKV4 Kappa None None None None None 2jix H L 0 E protein NA erythropoietin receptor RECEPTOR/IMMUNE SYSTEM 07/02/07 Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor ESCHERICHIA COLI; HOMO SAPIENS homo sapiens Liu, Z., Stoll, V.S., DeVries, P., Jakob, C.G., Xie, N., Simmer, R.L., Lacy, S.E., Egan, D.A., Harlan, J.E., Lesniewski, R.R., Reilly, E.B. 3.2 X-RAY DIFFRACTION 0.323 0.257 False True IGHV4 IGKV1 Kappa 3.00E-08 -10.26 17620453 5c0n H L 0 A protein NA fatty acid-binding protein, adipocyte LIPID TRANSPORT 06/12/15 Development of a monoclonal antibody targeting secreted aP2 to treat diabetes and fatty liver disease ORYCTOLAGUS CUNICULUS; MUS MUSCULUS oryctolagus cuniculus oryctolagus cuniculus mus musculus Doyle, C. 3.0 X-RAY DIFFRACTION 0.265 0.186 False True IGHV1 IGKV1 Kappa None None None None None 4qxt A B 0 Q peptide NA merozoite surface antigen 2 IMMUNE SYSTEM 07/22/14 Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with FC27-MSP2 14-30 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum k1 Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S. 1.58 X-RAY DIFFRACTION 0.177 0.156 False True IGHV14 IGKV3 Kappa None None None None None 4g6j H L 0 A protein NA interleukin-1 beta IMMUNE SYSTEM 07/19/12 Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab homo sapiens homo sapiens homo sapiens Blech, M., Hoerer, S. 2.03 X-RAY DIFFRACTION 0.252 0.226 False True IGHV3 IGKV1 Kappa None None None 2hkf H L 0 P peptide NA carbonic anhydrase 9 immune system 07/04/06 Crystal structure of the Complex Fab M75- Peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kral, V., Mader, P., Stouracova, R., Fabry, M., Horejsi, M., Brynda, J. 2.01 X-RAY DIFFRACTION 0.242 0.176 False False IGHV10 IGKV1 Kappa 3.10E-07 -8.89 18041760 4r0l A B 0 C protein NA t-cell costimulatory molecule cd28 IMMUNE SYSTEM 07/31/14 Anti-canine CD28 antibody, 1C6, bound canine CD28 CANIS LUPUS FAMILIARIS; MUS MUSCULUS mus musculus canis lupus familiaris mus musculus Gewe, M.M., Strong, R.K. 3.3 X-RAY DIFFRACTION 0.293 0.256 False True IGHV9 IGKV2 Kappa None None None None None 3qwo A B 0 C protein NA motavizumab epitope scaffold Immune System 02/28/11 Crystal structure of a motavizumab epitope-scaffold bound to motavizumab Fab MUS MUSCULUS; STAPHYLOCOCCUS AUREUS mus musculus mus musculus staphylococcus aureus McLellan, J.S., Kwong, P.D. 1.9 X-RAY DIFFRACTION 0.231 0.188 False True IGHV2 IGKV1 Kappa 8.70E-08 -9.63 21549714 3v7a E H 0 A protein NA capsid IMMUNE SYSTEM 12/20/11 Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle HUMAN CALICIVIRUS; MUS MUSCULUS mus musculus mus musculus human calicivirus Hansman, G.S., Mclellan, J.S., Kwong, P.D. 3.297 X-RAY DIFFRACTION 0.283 0.227 False False IGHV1 IGKV12 Kappa None None None 4ki5 E F 0 M protein NA coagulation factor viii IMMUNE SYSTEM 05/01/13 Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Walter, J.D., Meeks, S.L., Healey, J.F., Lollar, P., Spiegel, P.C. 2.47 X-RAY DIFFRACTION 0.238 0.188 False False IGHV1 IGKV9 Kappa None None None None None 3wxw H L 0 A protein NA adiponectin receptor protein 2 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/11/14 Crystal structure of the human adiponectin receptor 2 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S. 2.4 X-RAY DIFFRACTION 0.290 0.248 False True IGHV1 IGKV12 Kappa None None None None None 2r29 H L 0 A protein NA envelope protein e Viral protein/Immune system 08/24/07 Neutralization of dengue virus by a serotype cross-reactive antibody elucidated by cryoelectron microscopy and x-ray crystallography DENGUE VIRUS 2 THAILAND/16681/84; MUS MUSCULUS mus musculus mus musculus dengue virus 2 thailand/16681/84 Lok, S.M., Kostyuchenko, V.K., Nybakken, G.E., Holdaway,H.A, Battisti, A.J., Sukupolvi-petty,S., Sedlak,D., Fremont, D.H., Chipman, P.R., Roehrig, J.T., Diamond, M.S., Kuhn, R.J., Rossmann, M.G. 3.0 X-RAY DIFFRACTION 0.321 0.259 False False IGHV14 IGKV3 Kappa None None None 2oqj K J 0 L peptide NA peptide 2g12.1 (acppshvldmrsgtclaaegk) Immune system 01/31/07 Crystal structure analysis of Fab 2G12 in complex with peptide 2G12.1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Menendez, A., Scott, J.K., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.275 0.234 False False IGHV3 IGKV1 Kappa 2.00E-04 -5.04 18198210 1n0x K M 0 R peptide NA b2.1 peptide IMMUNE SYSTEM 10/15/02 Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Saphire, E.O., Montero, M., Menendez, A., Irving, M.B., Zwick, M.B., Parren, P.W.H.I., Burton, D.R., Scott, J.K., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.252 0.220 False True IGHV1 IGKV3 Kappa None None None 3iet B A 0 X peptide NA podoplanin IMMUNE SYSTEM 07/23/09 Crystal Structure of 237mAb with antigen MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V., Borisova, S.N. 2.2 X-RAY DIFFRACTION 0.271 0.227 False True IGHV6 IGKV1 Kappa None None None 4k2u I M 0 B protein NA erythrocyte binding antigen 175 IMMUNE SYSTEM 04/09/13 Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Tolia, N.H. 2.45 X-RAY DIFFRACTION 0.253 0.204 False False IGHV14 IGKV10 Kappa None None None 2g5b B A 0 I peptide NA bax peptide APOPTOSIS 02/22/06 Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Peyerl, F.W., Dai, S., Murphy, G.A., Marrack, P., Kappler, J.W. 2.3 X-RAY DIFFRACTION 0.275 0.234 False True IGHV7 IGKV8 Kappa None None None 3r1g H L 0 B protein NA beta-secretase 1 PROTEIN BINDING 03/10/11 Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, W., Rouge, L., Wu, P., Chiu, C., Chen, Y., Wu, Y., Watts, R.J. 2.8 X-RAY DIFFRACTION 0.268 0.222 False False IGHV3 IGKV1 Kappa 1.30E-09 -12.12 21613622 4o51 D C 0 O peptide NA ides hinge peptide IMMUNE SYSTEM 12/19/13 Crystal structure of the QAA variant of anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide ORYCTOLAGUS CUNICULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens homo sapiens Malia, T.J., Luo, J., Teplyakov, A., Gilliland, G.L. 2.204 X-RAY DIFFRACTION 0.213 0.182 False True IGHV1 IGKV1 Kappa None None None None None 2oz4 H L 0 A protein NA intercellular adhesion molecule 1 CELL ADHESION 02/23/07 Structural Plasticity in IgSF Domain 4 of ICAM-1 Mediates Cell Surface Dimerization HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chen, X., Kim, T.D., Carman, C.V., Mi, L., Song, G., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.253 0.204 False False IGHV1 IGKV5 Kappa None None None 3vrl H L 0 C protein NA gag protein IMMUNE SYSTEM/VIRAL PROTEIN 04/12/12 Crystal structure of BMJ4 p24 capsid protein in complex with A10F9 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Gu, Y., Cao, F., Li, S., Yuan, Y.A., Xia, N. 3.2 X-RAY DIFFRACTION 0.292 0.211 False False IGHV5 IGKV12 Kappa None None None 3e8u H L 0 P peptide NA bnp peptide epitope IMMUNE SYSTEM 08/20/08 Crystal structure and thermodynamic analysis of diagnostic Fab 106.3 complexed with BNP 5-13 (C10A) reveal basis of selective molecular recognition MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Longenecker, K.L., Ruan, Q., Fry, E.H., Saldana, S.S., Brophy, S.E., Richardson, P.L., Tetin, S.Y. 2.1 X-RAY DIFFRACTION 0.243 0.185 False True IGHV9 IGKV3 Kappa 2.00E-10 -13.14 19274732 4g7v H L 0 S protein NA voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.5 A) CIONA INTESTINALIS; HOMO SAPIENS homo sapiens homo sapiens ciona intestinalis Li, Q. 2.5 X-RAY DIFFRACTION 0.240 0.201 False True IGHV3 IGKV1 Kappa None None None None None 2brr H L 0 P peptide NA class 1 outer membrane protein variable region 2 IMMUNE SYSTEM 05/11/05 Complex of the neisserial PorA P1.4 epitope peptide and two Fab- fragments (antibody MN20B9.34) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Oomen, C.J., Hoogerhout, P., Kuipers, B., Vidarsson, G., vanAlphen, L., Gros, P. 1.95 X-RAY DIFFRACTION 0.238 0.198 False True IGHV9 IGKV4 Kappa None None None 4tuj A B 0 E peptide NA peptide1 IMMUNE SYSTEM 06/24/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Grudnik, P., Golik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G. 1.89 X-RAY DIFFRACTION 0.232 0.179 False True IGHV1 IGKV1 Kappa None None None None None 3eyf D C 0 F peptide NA synthetic peptide IMMUNE SYSTEM 10/20/08 Crystal structure of anti-human cytomegalovirus antibody 8f9 plus gB peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.3 X-RAY DIFFRACTION 0.230 0.210 False True IGHV3 IGKV3 Kappa 9.40E-08 -9.3 18772881 3ve0 A B 0 J protein NA envelope glycoprotein Immune system/viral protein 01/06/12 Crystal structure of Sudan Ebolavirus Glycoprotein (strain Boniface) bound to 16F6 SUDAN EBOLAVIRUS; MUS MUSCULUS mus musculus mus musculus sudan ebolavirus Saphire, E.O., Bale, S., Dias, J.M. 3.353 X-RAY DIFFRACTION 0.289 0.222 False False IGHV5 IGKV6 Kappa None None None 4i3s H L 0 G protein NA outer domain of hiv-1 gp120 (ker2018 od4.2.2) Viral Protein/Immune System 11/26/12 Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P21 HUMAN IMMUNODEFICIENCY VIRUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus Joyce, M.G., Biertumpfel, C., Nabel, G.J., Kwong, P.D. 2.85 X-RAY DIFFRACTION 0.320 0.248 False True unknown unknown unknown None None None 2jel H L 0 P protein NA histidine-containing protein COMPLEX (ANTIBODY/ANTIGEN) 02/24/98 JEL42 FAB/HPR COMPLEX MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Prasad, L., Waygood, E.B., Lee, J.S., Delbaere, L.T.J. 2.5 X-RAY DIFFRACTION 0.280 0.210 False False IGHV1 IGKV1 Kappa 3.70E-09 -11.49 9671548 3vg9 C B 0 A protein NA adenosine receptor a2a SIGNALING PROTEIN 08/04/11 Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T. 2.7 X-RAY DIFFRACTION 0.246 0.206 False False IGHV1 IGKV12 Kappa None None None 1ncb H L 0 N protein NA influenza a subtype n9 neuraminidase HYDROLASE(O-GLYCOSYL) 01/21/92 CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Tulip, W.R., Varghese, J.N., Colman, P.M. 2.5 X-RAY DIFFRACTION unknown 0.165 False False IGHV9 IGKV6 Kappa None None None 4cad H G 0 I protein NA ras and a-factor converting enzyme 1, rce1 PROTEIN BINDING 10/08/13 Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 METHANOCOCCUS MARIPALUDIS; MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis Kulkarni, K., Manolaridis, I., Dodd, R.B., Cronin, N., Ogasawara, S., Iwata, S., Barford, D. 2.5 X-RAY DIFFRACTION 0.2669 0.2262 False False IGHV1 IGKV12 Kappa None None None None None 4p59 H L 0 A protein NA receptor tyrosine-protein kinase erbb-3 Signaling protein, immune system 03/15/14 HER3 extracellular domain in complex with Fab fragment of MOR09825 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Sprague, E.R. 3.4 X-RAY DIFFRACTION 0.250 0.184 False True IGHV3 IGKV1 Kappa None None None None None 1uj3 B A 0 C protein NA tissue factor IMMUNE SYSTEM/BLOOD CLOTTING 07/25/03 Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ohto, U., Mizutani, R., Nakamura, M., Adachi, H., Satow, Y. 2.1 X-RAY DIFFRACTION 0.227 0.196 False True IGHV1 IGKV1D Kappa None None None 4dn4 H L 0 M protein NA c-c motif chemokine 2 IMMUNE SYSTEM 02/08/12 Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Obmolova, G., Teplyakov, A., Malia, T., Grygiel, T., Sweet, R., Snyder L., Gilliland, G. 2.8 X-RAY DIFFRACTION 0.266 0.196 False True IGHV1 IGKV3 Kappa None None None 1pkq G F 0 J protein NA myelin oligodendrocyte glycoprotein IMMUNE SYSTEM 06/06/03 Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Breithaupt, C., Schubart, A., Zander, H., Skerra, A., Huber, R., Linington, C., Jacob, U. 3.0 X-RAY DIFFRACTION 0.319 0.250 False True IGHV1 IGKV8 Kappa None None None 2vh5 H L 0 R protein NA gtpase hras IMMUNE SYSTEM 11/19/07 CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tanaka, T., Williams, R.L., Rabbitts, T.H. 2.7 X-RAY DIFFRACTION 0.291 0.211 False True IGHV3 IGKV1 Kappa None None None 1i8k B A 0 C peptide NA epidermal growth factor receptor, egfrviiipeptide antigen IMMUNE SYSTEM 03/14/01 CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Landry, R.C., Klimowicz, A.C., Lavictoire, S.J., Borisova, S., Kottachchi, D.T., Lorimer, I.A., Evans, S.V. 1.8 X-RAY DIFFRACTION 0.224 0.172 False True IGHV5 IGKV17 Kappa 2.20E-08 -10.44 11352579 3loh A B 0 E protein NA insulin receptor IMMUNE SYSTEM/HORMONE RECEPTOR 02/03/10 Structure of the insulin receptor ectodomain, including ct peptide MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Lawrence, M.C., Smith, B.J. 3.803 X-RAY DIFFRACTION 0.285 0.225 False True IGHV2 IGKV8 Kappa None None None 4xvs H L 0 G protein NA donor 45 01dg5 coree gp120 Viral protein/Immune system 01/27/15 Crystal structure of HIV-1 donor 45 d45-01dG5 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.9 X-RAY DIFFRACTION 0.214 0.194 False True unknown IGKV3 Kappa None None None None None 4lsr H L 0 G protein NA envelope glycoprotein gp120 with loop d and v5 from strainker_2018_11 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E stran 93TH057 gp120 with LOOP D and Loop V5 from clade A strain KER_2018_11 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.28 X-RAY DIFFRACTION 0.258 0.194 False True unknown IGKV1 Kappa None None None 4rdq G F 0 E protein NA bestrophin-1 TRANSPORT PROTEIN 09/19/14 Calcium-activated chloride channel bestrophin-1, from chicken, in complex with Fab antibody fragments, chloride and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Dickson, V.K., Pedi, L., Long, S.B. 2.85 X-RAY DIFFRACTION 0.234 0.217 False False IGHV1 IGKV12 Kappa None None None None None 4lss H L 0 G protein NA envelope glycoprotein gp120 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 clade A strain KER_2018_11 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.59 X-RAY DIFFRACTION 0.263 0.192 False True unknown IGKV3 Kappa None None None 2i9l H G 0 L protein NA virion membrane protein m25 IMMUNE SYSTEM/VIRAL PROTEIN 09/05/06 Structure of Fab 7D11 from a neutralizing antibody against the poxvirus L1 protein VACCINIA VIRUS; MUS MUSCULUS mus musculus mus musculus vaccinia virus Su, H.P., Golden, J.W., Gittis, A.G., Moss, B., Hooper, J.W., Garboczi, D.N. 3.1 X-RAY DIFFRACTION 0.259 0.240 False False IGHV1 IGKV8 Kappa None None None 2r56 H L 0 A protein NA beta-lactoglobulin IMMUNE SYSTEM 09/03/07 Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Niemi, M., Kallio, J.M., Hakulinen, N., Rouvinen, J. 2.8 X-RAY DIFFRACTION 0.291 0.246 False False IGHV3 IGKV1 Kappa 1.30E-09 -12.12 17997967 3hmx H L 0 A protein NA interleukin-12 subunit beta Cytokine/IMMUNE SYSTEM 05/29/09 Crystal structure of ustekinumab FAB/IL-12 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J. 3.0 X-RAY DIFFRACTION 0.303 0.211 False True IGHV5 IGKV1D Kappa None None None 4n8c I M 0 Y peptide NA extracellular domain of influenza matrix protein 2 IMMUNE SYSTEM 10/17/13 Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus influenza a virus (a/puerto rico/8/1934(h1n1)) Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H. 1.6 X-RAY DIFFRACTION 0.242 0.193 False False IGHV1 IGKV8 Kappa None None None None None 2y5t A B 0 E peptide NA c1 IMMUNE SYSTEM 01/17/11 Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Lindh, I., Schneider, N., Uysal, H., Nandakumar, K.S., Burkhardt, H., Schneider, G., Holmdahl, R. 2.2 X-RAY DIFFRACTION 0.24544 0.18845 False False IGHV1 IGKV3 Kappa None None None 3mnw B A 0 P peptide NA gp41 IMMUNE SYSTEM 04/22/10 Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide in a helical conformation MUS MUSCULUS,HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus,homo sapiens mus musculus,homo sapiens human immunodeficiency virus 1 Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 2.2 X-RAY DIFFRACTION 0.253 0.181 False True IGHV9 IGKV8 Kappa None None None 5cjq H L 0 B protein NA designed influenza hemagglutinin stem #4900, ha2 VIRAL PROTEIN/IMMUNE SYSTEM 07/14/15 Crystal structure of a trimeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Zhu, X., Wilson, I.A. 3.6 X-RAY DIFFRACTION 0.369 0.346 False True IGHV1 IGLV1 Lambda None None None None None 3gi9 H L 0 C protein NA uncharacterized protein mj0609 TRANSPORT PROTEIN 03/05/09 Crystal Structure of ApcT Transporter Bound to 7F11 Monoclonal Fab Fragment MUS MUSCULUS; METHANOCALDOCOCCUS JANNASCHII mus musculus mus musculus methanocaldococcus jannaschii Shaffer, P.L., Goehring, A.S., Shankaranarayanan, A., Gouaux, E., New York Consortium on Membrane Protein Structure (NYCOMPS) 2.48 X-RAY DIFFRACTION 0.296 0.248 False True IGHV1 IGKV8 Kappa None None None 1jhl H L 0 A protein NA pheasant egg white lysozyme COMPLEX(ANTIBODY-ANTIGEN) 05/04/93 THREE-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX MUS MUSCULUS; PHASIANUS COLCHICUS mus musculus mus musculus phasianus colchicus Chitarra, V., Alzari, P.M., Bentley, G.A., Bhat, T.N., Eisele, J.-L., Poljak, R.J. 2.4 X-RAY DIFFRACTION unknown 0.214 False True IGHV1 IGKV16 Kappa None None None 2ny3 D C 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E267C, S334A, S375W) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.243 0.203 False True IGHV1 IGKV3 Kappa None None None 4mxv H L 0 A protein NA lymphotoxin-alpha CYTOKINE/IMMUNE SYSTEM 09/26/13 Structure of Lymphotoxin alpha bound to anti-LTa Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, J.P., Hymowitz, S.G. 3.2 X-RAY DIFFRACTION 0.235 0.177 False True IGHV3 IGKV1 Kappa None None None None None 2igf H L 0 P peptide NA peptide (residues 69-87 of myohemerythrin) IMMUNOGLOBULIN 03/21/91 CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.220 False True IGHV5 IGKV1 Kappa None None None 4nrx A B 0 C peptide NA envelope glycoprotein gp41 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66 in complex with gp41 MPER peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Yang, Y., Kwong, P.D. 2.21 X-RAY DIFFRACTION 0.215 0.188 False True IGHV5 IGKV1 Kappa None None None None None 4ypg B A 0 C protein NA interferon alpha-2 IMMUNE SYSTEM 03/12/15 Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oganesyan, V., Dall'Acqua, W.F. 3.0 X-RAY DIFFRACTION 0.272 0.206 False True IGHV1 IGKV3 Kappa None None None None None 1kb5 H L 0 A protein NA kb5-c20 t-cell antigen receptor COMPLEX (IMMUNOGLOBULIN/RECEPTOR) 04/06/97 MURINE T-CELL RECEPTOR VARIABLE DOMAIN/FAB COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Housset, D., Mazza, G., Gregoire, C., Piras, C., Malissen, B., Fontecilla-Camps, J.C. 2.5 X-RAY DIFFRACTION unknown 0.219 False False IGHV1 IGKV12 Kappa None None None 4ij3 C B 0 A protein NA sulfhydryl oxidase 1 OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR 12/21/12 Oxidoreductase Fragment of Human QSOX1 in Complex with a FAB Fragment from an Anti- Human QSOX1 Antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Fass, D., Grossman, I. 2.7 X-RAY DIFFRACTION 0.237 0.202 False True IGHV2 IGKV6 Kappa None None None None None 3sm5 H L 0 A protein NA hemagglutinin IMMUNE SYSTEM 06/27/11 Influenza hemagglutinin in complex with a neutralizing antibody INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Whittle, J.R.R., Harrison, S.C. 3.195 X-RAY DIFFRACTION 0.249 0.211 False True IGHV1 IGLV3 Lambda None None None 4tqe H L 0 A peptide NA microtubule-associated protein tau IMMUNE SYSTEM 06/11/14 Structure of tau peptide in complex with Tau5 antibody Fab fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Cehlar, O., Skrabana, R., Novak, M. 1.6 X-RAY DIFFRACTION 0.197 0.151 False False IGHV14 IGKV1 Kappa None None None None None 4j8r B A 0 I peptide NA major prion protein IMMUNE SYSTEM 02/14/13 Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Swayampakula, M., Baral, P.K., Kav, N.N.V., Aguzzi, A., James, M.N.G. 2.303 X-RAY DIFFRACTION 0.257 0.247 False False IGHV1 IGKV6 Kappa None None None 2dd8 H L 0 S protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/24/06 Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody HOMO SAPIENS; SARS CORONAVIRUS homo sapiens homo sapiens sars coronavirus Prabakaran, P., Gan, J.H., Feng, Y., Zhu, Z.Y., Xiao, X.D., Ji, X., Dimitrov, D.S. 2.3 X-RAY DIFFRACTION 0.261 0.199 False True IGHV1 IGLV3 Lambda 2.00E-08 -10.5 16597622 4bz2 H L 0 A protein NA envelope protein IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX 07/23/13 Structure of dengue virus EDIII in complex with Fab 2D73 DENGUE VIRUS 4; MUS MUSCULUS mus musculus mus musculus dengue virus 4 Li, J., Watterson, D., Chang, C.W., Li, X.Q., Ericsson, D.J., Qiu, L.W., Cai, J.P., Chen, J., Fry, S.R., Cooper, M.A., Che, X.Y., Young, P.R., Kobe, B. 2.03 X-RAY DIFFRACTION 0.2247 0.2052 False False IGHV1 IGKV14 Kappa None None None None None 3c09 C B 0 A protein NA epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 01/18/08 Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR HOMO SAPIENS, MUS MUSCULUS; HOMO SAPIENS homo sapiens, mus musculus homo sapiens, mus musculus homo sapiens Ferguson, K.M., Schmiedel, J., Knoechel, T. 3.2 X-RAY DIFFRACTION 0.299 0.242 False True IGHV1 IGKV1 Kappa 4.30E-08 -10.04 18394559 3kj4 H L 0 A protein NA reticulon-4 receptor IMMUNE SYSTEM 11/02/09 Structure of rat Nogo receptor bound to 1D9 antagonist antibody RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Silvian, L.F. 3.1 X-RAY DIFFRACTION 0.318 0.253 False True IGHV2 IGKV8 Kappa None None None 3wd5 H L 0 A protein NA tumor necrosis factor IMMUNE SYSTEM 06/06/13 Crystal structure of TNFalpha in complex with Adalimumab Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hu, S., Liang, S.Y., Guo, Y.J., Lou, Z.Y. 3.101 X-RAY DIFFRACTION 0.275 0.187 False True IGHV3 IGKV1 Kappa None None None 3w2d H L 0 A protein NA enterotoxin type b IMMUNE SYSTEM 11/28/12 Crystal Structure of Staphylococcal Eenterotoxin B in complex with a novel neutralization monoclonal antibody Fab fragment STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Liang, S.Y., Hu, S., Dai, J.X., Guo, Y.J., Lou, Z.Y. 3.1 X-RAY DIFFRACTION 0.261 0.196 False True IGHV3 IGKV4 Kappa None None None None None 1uac H L 0 Y protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 03/08/03 Crystal Structure of HYHEL-10 FV MUTANT SFSF Complexed with TURKEY WHITE LYSOZYME MUS MUSCULUS; MELEAGRIS GALLOPAVO mus musculus mus musculus meleagris gallopavo Kumagai, I., Nishimiya, Y., Kondo, H., Tsumoto, K. 1.7 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV5 Kappa None None None 3hr5 J Q 0 V peptide NA m1prime-derived peptide IMMUNE SYSTEM 06/08/09 M1prime peptide from IgE bound by humanized antibody 47H4 Fab MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Eigenbrot, C.W., Ultsch, M.H. 2.4 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None 4mqx E F 0 B protein NA h(+)/cl(-) exchange transporter clca metal transport, membrane protein 09/16/13 CLC-ec1 Fab Complex Cysless A399C-A432C mutant ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Basilio, D., Noack, K., Picollo, A., Accardi, A. 3.516 X-RAY DIFFRACTION 0.258 0.223 False True IGHV4 IGKV4 Kappa None None None None None 4xh2 E F 0 e peptide NA unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD4 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.0 X-RAY DIFFRACTION 0.258 0.224 False True IGHV3 IGKV1 Kappa None None None None None 2y36 H L 0 P peptide NA dodecapeptide (dlwttaiptips) IMMUNE SYSTEM 12/18/10 Crystal structure analysis of the anti-(4-hydroxy-3-nitrophenyl)- acetyl murine germline antibody BBE6.12H3 Fab fragment in complex with a phage display derived dodecapeptide DLWTTAIPTIPS MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.7 X-RAY DIFFRACTION 0.2477 0.2305 False False IGHV1 IGLV1 Lambda None None None 4bh8 B A 0 P peptide NA dodecapeptide antigen IMMUNE SYSTEM 03/30/13 CRYSTAL STRUCTURE OF GERMLINE ANTIBODY 36-65 IN COMPLEX WITH PEPTIDE GDPRPSYISHLL MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.4 X-RAY DIFFRACTION 0.2510 0.2305 False False IGHV1 IGKV10 Kappa None None None None None 4xak H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM 12/15/14 Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD HUMAN CORONAVIRUS EMC; HOMO SAPIENS homo sapiens homo sapiens human coronavirus emc Zhou, T., Dimtrov, D.S., Ying, T. 2.45 X-RAY DIFFRACTION 0.249 0.198 False True IGHV1 IGKV1 Kappa None None None None None 3pp4 H L 0 P peptide NA b-lymphocyte antigen cd20 IMMUNE SYSTEM 11/24/10 Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for the type I / type II distinction of anti- CD20 antibodies MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Hopfner, K.-P., Lammens, A. 1.6 X-RAY DIFFRACTION 0.187 0.137 False True IGHV1 IGKV2D Kappa None None None 4zfo A B 0 F peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 04/21/15 J22.9-xi: chimeric mouse/human antibody against human BCMA (CD269) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Marino, S.F., Daumke, O., Olal, D. 1.895 X-RAY DIFFRACTION 0.209 0.176 False True IGHV4 IGKV6 Kappa None None None None None 3pgf H L 0 A protein NA maltose-binding periplasmic protein MALTODEXTRIN BINDING PROTEIN/DE NOVO PROTEIN 11/01/10 Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Kossiakoff, A.A., Duguid, E.M., Sandstrom, A. 2.1 X-RAY DIFFRACTION 0.227 0.177 False True IGHV3 IGKV1 Kappa None None None 4al8 H L 0 C protein NA envelope protein IMMUNE SYSTEM 03/02/12 Structure of Dengue virus DIII in complex with Fab 2H12 DENGUE VIRUS; HOMO SAPIENS homo sapiens homo sapiens dengue virus Midgley, C.M., Flanagan, A., Mongkolsapaya, J., Grimes, J.M., Screaton, G.R. 1.66 X-RAY DIFFRACTION 0.1975 0.1699 False False IGHV1 IGKV6 Kappa None None None 4n9g E F 0 D peptide NA epitope scaffold rsv_1isea_ffl_001_c IMMUNE SYSTEM 10/21/13 Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9 MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta synthetic construct Carrico, C.T.D., Strong, R.K. 2.5 X-RAY DIFFRACTION 0.295 0.263 False True IGHV4 IGKV1 Kappa None None None None None 4hlz G H 0 B protein NA hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 10/17/12 Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Dreyfus, C., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.228 False True IGHV7 IGKV12 Kappa None None None 3csy C D 0 N protein NA envelope glycoprotein gp2 IMMUNE SYSTEM/VIRAL PROTEIN 04/10/08 Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor HOMO SAPIENS; ZAIRE EBOLA VIRUS homo sapiens homo sapiens zaire ebola virus Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O. 3.4 X-RAY DIFFRACTION 0.302 0.261 False True IGHV3 IGKV4 Kappa None None None 4uu9 A B 0 C protein NA complement c5 07/25/14 Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Colley, C., Sridharan, S., Dobson, C., Popovic, B., Debreczeni, J.E., Hargreaves, D., Edwards, B., Brennan, J., England, L., Fung, S., An Eghobamien, L., Sivars, U., Woods, R., Flavell, L., Renshaw, G.J., Wickson, K., Wilkinson, T., Davies, R., Bonnell, J., Warrener, P., Howes, R., Vaughan, T. 2.12 X-RAY DIFFRACTION 0.20163 0.17456 False True IGHV3 IGLV2 Lambda None None None None None 2xqy J K 0 E protein NA envelope glycoprotein h IMMUNE SYSTEM/VIRAL PROTEIN 09/08/10 Crystal structure of Pseudorabies core fragment of glycoprotein H in complex with Fab d6.3 SUID HERPESVIRUS; MUS MUSCULUS mus musculus mus musculus suid herpesvirus Backovic, M., Dubois, R., Cockburn, J., Sharff, A., Vaney, M., Granzow, H., Klupp, B., Bricogne, G., Mettenleiter, T., Rey, F. 2.05 X-RAY DIFFRACTION 0.2046 0.1878 False True IGHV1 IGKV3 Kappa None None None 3ubx H L 0 A protein NA antigen-presenting glycoprotein cd1d1 IMMUNE SYSTEM 10/25/11 Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex MUS MUSCULUS mus musculus mus musculus mus musculus Yu, E.D., Zajonc, D.M. 3.1 X-RAY DIFFRACTION 0.230 0.202 False False IGHV9 IGKV13 Kappa None None None 4plj H L 0 A protein NA capsid protein VIRAL PROTEIN/IMMUME SYSTEM 05/18/14 Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing antibody 8G12 HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Li, S.W., Sivaraman, J. 2.3 X-RAY DIFFRACTION 0.242 0.187 False False IGHV1 IGKV12 Kappa None None None None None 2qhr H L 0 P peptide NA envelope glycoprotein peptide Immune system/viral protein 07/02/07 Crystal structure of the 13F6-1-2 Fab fragment bound to its Ebola virus glycoprotein peptide epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Lee, J.E., Kuehne, A., Abelson, D.M., Fusco, M.L., Hart, M.K., Saphire, E.O. 2.0 X-RAY DIFFRACTION 0.245 0.203 False False IGHV5 IGLV3 Lambda 4.10E-08 -10.07 18005986 4r2g N M 0 A protein NA surface protein gp160 IMMUNE SYSTEM 08/11/14 Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (JRCSF ISOLATE); HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 (jrcsfisolate) Garces, F., Wilson, I.A. 3.283 X-RAY DIFFRACTION 0.263 0.207 False True IGHV4 IGLV3 Lambda None None None None None 1fns H L 0 A protein NA von willebrand factor IMMUNE SYSTEM 08/23/00 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Varughese, K.I. 2.0 X-RAY DIFFRACTION 0.207 0.172 False False IGHV2 IGKV10 Kappa None None None 4h88 H L 0 A protein NA major prion protein IMMUNE SYSTEM 09/21/12 Structure of POM1 FAB fragment complexed with mouse PrPc Fragment 120-230 MUS MUSCULUS mus musculus mus musculus mus musculus Baral, P.K., Wieland, B., Swayampakula, M., James, M.N. 1.9 X-RAY DIFFRACTION 0.234 0.199 False False IGHV1 IGKV5 Kappa None None None 4g6f H L 0 P peptide NA gp41 mper peptide IMMUNE SYSTEM 07/19/12 Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Huang, J., Connors, M., Kwong, P.D. 2.1 X-RAY DIFFRACTION 0.218 0.180 False True IGHV3 IGLV3 Lambda None None None 1oaz J N 0 B protein NA thioredoxin 1 IMMUNE SYSTEM 01/21/03 IgE Fv SPE7 complexed with a recombinant thioredoxin RATTUS RATTUS; ESCHERICHIA COLI rattus rattus rattus rattus escherichia coli James, L.C., Roversi, P., Tawfik, D. 2.78 X-RAY DIFFRACTION 0.276 0.208 False True IGHV1 IGLV1 Lambda None None None 2fd6 H L 0 U protein NA urokinase plasminogen activator surface receptor IMMUNE SYSTEM, HYDROLASE 12/13/05 Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Huang, M., Huai, Q., Li, Y. 1.9 X-RAY DIFFRACTION 0.276 0.239 False False IGHV1 IGKV4 Kappa None None None 1h0d B A 0 C protein NA angiogenin IMMUNE SYSTEM/HYDROLASE 06/19/02 Crystal structure of Human Angiogenin in complex with Fab fragment of its monoclonal antibody mAb 26-2F HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chavali, G.B., Papageorgiou, A.C., Acharya, K.R. 2.0 X-RAY DIFFRACTION 0.272 0.232 False True IGHV5 IGKV3 Kappa None None None 4jg0 H L 0 P peptide NA phosphopeptide immune system 02/28/13 Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide ESCHERICHIA COLI; SYNTHETIC CONSTRUCT Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 1.81 X-RAY DIFFRACTION 0.202 0.161 False True IGHV3 IGKV3 Kappa None None None 1rjl B A 0 C protein NA outer surface protein b IMMUNE SYSTEM 11/19/03 Structure of the complex between OspB-CT and bactericidal Fab-H6831 BORRELIA BURGDORFERI; MUS MUSCULUS mus musculus mus musculus borrelia burgdorferi Becker, M., Bunikis, J., Lade, B.D., Dunn, J.J., Barbour, A.G., Lawson, C.L. 2.6 X-RAY DIFFRACTION 0.235 0.191 False False IGHV1 IGKV15 Kappa None None None 2arj H L 0 Q protein NA t-cell surface glycoprotein cd8 alpha chain Immune System 08/19/05 CD8alpha-alpha in complex with YTS 105.18 Fab MUS MUSCULUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Shore, D.A., Teyton, L., Dwek, R.A., Rudd, P.M., Wilson, I.A. 2.88 X-RAY DIFFRACTION 0.277 0.220 False False IGHV2 IGKV6 Kappa None None None 1osp H L 0 O protein NA outer surface protein a COMPLEX (IMMUNOGLOBULIN/LIPOPROTEIN) 11/23/96 CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB BORRELIA BURGDORFERI; MUS MUSCULUS mus musculus mus musculus borrelia burgdorferi Li, H., Lawson, C.L. 1.95 X-RAY DIFFRACTION 0.295 0.229 False False IGHV3 IGKV13 Kappa None None None 4bz1 H L 0 A protein NA envelope protein IMMUNE SYSTEM/VIRAL PROTEIN 07/23/13 Structure of dengue virus EDIII in complex with Fab 3e31 DENGUE VIRUS 4; MUS MUSCULUS mus musculus mus musculus dengue virus 4 Li, J., Watterson, D., Chang, C.W., Li, X.Q., Ericsson, D.J., Qiu, L.W., Cai, J.P., Chen, J., Fry, S.R., Cooper, M.A., Che, X.Y., Young, P.R., Kobe, B. 2.15 X-RAY DIFFRACTION 0.2546 0.2234 False False IGHV1 IGKV8 Kappa None None None None None 4lsv H L 0 G protein NA envelope glycoprotein gp120 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody 3BNC117 in complex with HIV-1 clade C C1086 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 3.0 X-RAY DIFFRACTION 0.299 0.260 False True unknown IGKV1 Kappa None None None 2hmi D C 0 B protein NA hisubunit of v-1 reverse transcriptase IMMUNE SYSTEM/DNA 04/10/98 HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Ding, J., Das, K., Hsiou, Y., Sarafianos, S.G., Clark Jr., A.D., Jacobo-Molina, A., Tantillo, C., Hughes, S.H., Arnold, E. 2.8 X-RAY DIFFRACTION 0.352 0.271 False False IGHV8 IGKV10 Kappa None None None 4jqi H L 0 A protein NA beta-arrestin-1 SIGNALING PROTEIN 03/20/13 Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide MUS MUSCULUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus Shukla, A.K., Manglik, A., Kruse, A.C., Xiao, K., Reis, R.I., Tseng, W.C., Staus, D.P., Hilger, D., Uysal, S., Huang, L.H., Paduch, M., Shukla, P.T., Koide, A., Koide, S., Weis, W.I., Kossiakoff, A.A., Kobilka, B.K., Lefkowitz, R.J. 2.6 X-RAY DIFFRACTION 0.247 0.201 False True IGHV3 IGKV1 Kappa None None None 1bql H L 0 Y protein NA bobwhite quail lysozyme ANTIBODY/ANTIGEN 02/03/95 STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME MUS MUSCULUS; COLINUS VIRGINIANUS mus musculus mus musculus colinus virginianus Chacko, S., Davies, D.R. 2.6 X-RAY DIFFRACTION 0.291 0.191 False True IGHV1 IGKV4 Kappa None None None 3ld8 C B 0 A protein NA bifunctional arginine demethylase and lysyl-hydroxylasejmjd6 IMMUNE SYSTEM 01/12/10 Structure of JMJD6 and Fab Fragments HOMO SAPIENS; CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius homo sapiens Hong, X., Zang, J., White, J., Kappler, J.W., Wang, C., Zhang, G. 2.7 X-RAY DIFFRACTION 0.260 0.233 False True IGHV3 IGKV8 Kappa None None None 1w72 H L 0 A protein NA hla class i histocompatibility antigen IMMUNE SYSTEM 08/27/04 Crystal structure of HLA-A1:MAGE-A1 in complex with Fab-Hyb3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Hulsmeyer, M., Chames, P., Hillig, R.C., Stanfield, R.L., Held, G., Coulie, P.G., Alings, C., Wille, G., Saenger, W., Ziegler, B.Uchanska-, Hoogenboom, H.R., Zieger, A. 2.15 X-RAY DIFFRACTION 0.248 0.182 False True IGHV3 IGLV3 Lambda 1.40E-08 -10.71 15537658 2dtg C D 0 E protein NA insulin receptor HORMONE RECEPTOR/IMMUNE SYSTEM 07/12/06 Insulin receptor (IR) ectodomain in complex with fab's MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Lawrence, M.C., Streltsov, V.A. 3.8 X-RAY DIFFRACTION 0.310 0.247 False True IGHV1 IGKV9 Kappa None None None 2qqn H L 0 A protein NA neuropilin-1 SIGNALING PROTEIN 07/26/07 Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Appleton, B.A., Wiesmann, C. 2.2 X-RAY DIFFRACTION 0.207 0.159 False True IGHV3 IGKV1 Kappa None None None 3ulu F E 0 A protein NA toll-like receptor 3 IMMUNE SYSTEM 11/11/11 Structure of quaternary complex of human TLR3ecd with three Fabs (Form1) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 3.52 X-RAY DIFFRACTION 0.309 0.268 False True IGHV1 IGKV12 Kappa None None None 2ypv H L 0 A protein NA lipoprotein IMMUNE SYSTEM 11/01/12 Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody NEISSERIA MENINGITIDIS MC58; MUS MUSCULUS mus musculus mus musculus neisseria meningitidis mc58 Malito, E., Veggi, D., Bottomley, M.J. 1.8 X-RAY DIFFRACTION 0.2246 0.1812 False False IGHV1 IGKV14 Kappa None None None 3p0y H L 0 A protein NA epidermal growth factor receptor IMMUNE SYSTEM 09/29/10 anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Shia, S. 1.8 X-RAY DIFFRACTION 0.215 0.181 False True IGHV3 IGKV1 Kappa 1.92E-09 -12.36 22014573 4zfg H L 0 A protein NA angiopoietin-2 SIGNALING PROTEIN/IMMUNE SYSTEM 04/21/15 Dual-specificity Fab 5A12 in complex with Angiopoietin 2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Harris, S.F., Wu, P. 2.27 X-RAY DIFFRACTION 0.223 0.177 False True IGHV3 IGKV1 Kappa None None None None None 2xzq H L 0 P peptide NA phage display derived antigen IMMUNE SYSTEM 12/01/10 CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-(4-HYDROXY-3-NITROPHENYL)- ACETYL MURINE GERMLINE MONOCLONAL ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE YQLRPNAETLRF MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.4 X-RAY DIFFRACTION 0.2506 0.2407 False False IGHV1 IGLV1 Lambda None None None 2vxq H L 0 A protein NA pollen allergen phl p 2 ALLERGEN 07/08/08 Crystal structure of the major grass pollen allergen Phl p 2 in complex with its specific IgE-Fab PHLEUM PRATENSE; HOMO SAPIENS homo sapiens homo sapiens phleum pratense Padavattan, S., Flicker, S., Schirmer, T., Madritsch, C., Randow, S., Reese, G., Vieths, S., Lupinek, C., Ebner, C., Rudolf, V., Markovic-Housley, Z. 1.9 X-RAY DIFFRACTION 0.226 0.177 False True IGHV4 IGKV1 Kappa 1.10E-10 -13.58 19201867 4okv C D 0 E protein NA anti-platelet aggregation protein BLOOD CLOTTING 01/23/14 Crystal structure of anopheline anti-platelet protein with Fab antibody ANOPHELES STEPHENSI; MUS MUSCULUS mus musculus mus musculus anopheles stephensi Park, S.Y., Sugiyama, K. 1.802 X-RAY DIFFRACTION 0.250 0.218 False False IGHV1 IGKV1 Kappa None None None None None 2h1p H L 0 P peptide NA pa1 COMPLEX (ANTIBODY/PEPTIDE) 11/12/97 THE THREE-DIMENSIONAL STRUCTURES OF A POLYSACCHARIDE BINDING ANTIBODY TO CRYPTOCOCCUS NEOFORMANS AND ITS COMPLEX WITH A PEPTIDE FROM A PHAGE DISPLAY LIBRARY: IMPLICATIONS FOR THE IDENTIFICATION OF PEPTIDE MIMOTOPES MUS MUSCULUS mus musculus mus musculus Young, A.C.M., Valadon, P., Casadevall, A., Scharff, M.D., Sacchettini, J.C. 2.4 X-RAY DIFFRACTION unknown 0.186 False False IGHV5 IGKV1 Kappa None None None 3q3g K J 0 L protein NA integrin alpha-m IMMUNE SYSTEM/CELL ADHESION 12/21/10 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 2.7 X-RAY DIFFRACTION 0.244 0.211 False False IGHV14 IGKV8 Kappa 4.97E-09 -11.32 22095715 1orq B A 0 C protein NA potassium channel MEMBRANE PROTEIN 03/14/03 X-ray structure of a voltage-dependent potassium channel in complex with an Fab AEROPYRUM PERNIX; MUS MUSCULUS mus musculus mus musculus aeropyrum pernix Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. 3.2 X-RAY DIFFRACTION 0.298 0.253 False False IGHV3 IGKV4 Kappa None None None 3grw H L 0 A protein NA fibroblast growth factor receptor 3 TRANSFERASE/IMMUNE SYSTEM 03/26/09 FGFR3 in complex with a Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 2.1 X-RAY DIFFRACTION 0.228 0.189 False True IGHV3 IGKV1 Kappa None None None 4f3f B A 0 C protein NA mesothelin IMMUNE SYSTEM 05/09/12 Crystal Structure of Msln7-64 MORAb-009 FAB complex HOMO SAPIENS; ESCHERICHIA COLI homo sapiens Xia, D., Pastan, I., Ma, J., Tang, W.K., Esser, L. 2.65 X-RAY DIFFRACTION 0.222 0.177 False True IGHV1 IGKV4 Kappa None None None 1uwx H L 0 P peptide NA class 1 outer membrane protein variable region 2 IMMUNE SYSTEM 02/12/04 P1.2 serosubtype antigen derived from N. meningitidis PorA in complex with Fab fragment STREPTOCOCCUS SP.; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Tzitzilonis, C., Prince, S.M., Collins, R.F., Maiden, M.C.J., Feavers, I.M., Derrick, J.P. 2.2 X-RAY DIFFRACTION 0.265 0.223 False False IGHV9 IGKV12 Kappa 1.60E-06 -7.9 16470851 2j4w H L 0 D peptide NA apical membrane antigen 1 IMMUNE SYSTEM 09/07/06 Structure of a Plasmodium vivax apical membrane antigen 1-Fab F8.12. 18 complex PLASMODIUM VIVAX; MUS MUSCULUS mus musculus mus musculus plasmodium vivax Igonet, S., Vulliez-Le Normand, B., Faure, G., Riottot, M.M., Kocken, C.H.M., Thomas, A.W., Bentley, G.A. 2.5 X-RAY DIFFRACTION 0.241 0.187 False False IGHV5 IGKV4 Kappa 6.00E-10 -12.57 17229439 3cx5 J K 0 E protein NA cytochrome b-c1 complex subunit rieske,mitochondrial OXIDOREDUCTASE 04/23/08 Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Solmaz, S.R.N., Hunte, C. 1.9 X-RAY DIFFRACTION 0.263 0.245 False True IGHV3 IGKV10 Kappa None None None 1xgy H L 0 P peptide NA rhodopsin epitope mimetic peptide immune system 09/17/04 Crystal Structure of Anti-Meta I Rhodopsin Fab Fragment K42-41L MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Piscitelli, C.L., Angel, T.E., Bailey, B.W., Lawerence, C.M. 2.71 X-RAY DIFFRACTION 0.272 0.233 False False IGHV1 IGKV2 Kappa None None None 4q6i B A 0 K protein NA t-cell surface glycoprotein cd4 IMMUNE SYSTEM 04/22/14 Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Boyington, J.C., Nabel, G.J., Mascola, J.R. 3.65 X-RAY DIFFRACTION 0.257 0.226 False False IGHV9 IGKV3 Kappa None None None None None 3pnw T S 0 U protein NA tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB SYNTHETIC; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None 3tt3 H L 0 A protein NA leucine transporter leut TRANSPORT PROTEIN 09/13/11 Crystal Structure of LeuT in the inward-open conformation in complex with Fab AQUIFEX AEOLICUS; MUS MUSCULUS mus musculus mus musculus aquifex aeolicus Krishnamurthy, H., Gouaux, E. 3.22 X-RAY DIFFRACTION 0.300 0.257 False True IGHV1 IGKV3 Kappa None None None 3ab0 B C 0 A protein NA bcla protein IMMUNE SYSTEM 11/28/09 Crystal structure of complex of the Bacillus anthracis major spore surface protein BclA with ScFv antibody fragment BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus mus musculus bacillus anthracis Streltsov, V.A. 3.09 X-RAY DIFFRACTION 0.265 0.197 False True IGHV5 IGKV4 Kappa None None None 3hb3 C D 0 B protein NA cytochrome c oxidase subunit 2 OXIDOREDUCTASE 05/04/09 High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase PARACOCCUS DENITRIFICANS; MUS MUSCULUS mus musculus mus musculus paracoccus denitrificans Koepke, J., Angerer, H., Peng, G. 2.25 X-RAY DIFFRACTION 0.280 0.218 False True IGHV5 IGKV12 Kappa None None None 3iu3 H L 0 I protein NA interleukin-2 receptor alpha chain IMMUNE SYSTEM 08/29/09 Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Du, J., Yang, H., Wang, J., Ding, J. 2.9 X-RAY DIFFRACTION 0.262 0.215 False True IGHV1 IGKV4 Kappa 1.40E-10 -13.44 20032294 4ogy M N 0 B protein NA plasma kallikrein HYDROLASE/ANTIBODY 01/16/14 Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Edwards, T.E., Clifton, M.C., Abendroth, J., Nixon, A., Ladner, R. 2.1 X-RAY DIFFRACTION 0.221 0.183 False True IGHV3 IGKV1 Kappa None None None None None 4aei H L 0 A protein NA alpha-mammal toxin aah2 IMMUNE SYSTEM/TOXIN 01/10/12 Crystal structure of the AaHII-Fab4C1 complex ANDROCTONUS AUSTRALIS HECTOR; MUS MUSCULUS mus musculus mus musculus androctonus australis hector Fabrichny, I.P., Mondielli, G., Conrod, S., Martin-Eauclaire, M.F., Bourne, Y., Marchot, P. 2.3 X-RAY DIFFRACTION 0.25403 0.19862 False False IGHV5 IGKV1 Kappa None None None 4kht H L 0 A protein NA gp41 helix immune system 05/01/13 Triple helix bundle of GP41 complexed with fab 8066 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Li, M., Gustchina, A,, Wlodawer, A. 2.817 X-RAY DIFFRACTION 0.266 0.215 False False IGHV1 IGLV3 Lambda None None None None None 2zch H L 0 P protein NA prostate-specific antigen IMMUNE SYSTEM 11/08/07 Crystal structure of human prostate specific antigen complexed with an activating antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Menez, R., Stura, E., Jolivet-Reynaud, C. 2.83 X-RAY DIFFRACTION 0.270 0.203 False False IGHV1 IGKV3 Kappa None None None 3idx H L 0 G protein NA hiv-1 hxbc2 gp120 core IMMUNE SYSTEM 07/22/09 Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C222 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chen, L., Kwon, Y.D., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z.Y., Zhang, M.Y., Arthos, J., Burton, D.R., Dimitrov, D.S., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.239 0.178 False True IGHV3 IGKV1 Kappa None None None 3vi3 F E 0 B protein NA integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 09/21/11 Crystal structure of alpha5beta1 integrin headpiece (ligand-free form) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nagae, M., Nogi, T., Takagi, J. 2.9 X-RAY DIFFRACTION 0.267 0.207 False True IGHV1 IGKV2 Kappa None None None 3nh7 H L 0 A protein NA bone morphogenetic protein receptor type-1a IMMUNE SYSTEM 06/14/10 Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mueller, T.D., Harth, S., Sebald, W. 2.7 X-RAY DIFFRACTION 0.280 0.234 False True IGHV3 IGLV3 Lambda 2.00E-08 -10.5 20927405 4nnp H L 0 A protein NA lipoprotein TRANSPORT PROTEIN/IMMUNE SYSTEM 11/18/13 Crystal Structure of Apo Manganese ABC transporter MntC from Staphylococcus aureus bound to an antagonistic fab fragment HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS homo sapiens homo sapiens staphylococcus aureus subsp. aureus Rouge, L., Sudhamsu, J. 2.69 X-RAY DIFFRACTION 0.283 0.224 False True IGHV3 IGKV1 Kappa None None None None None 1nsn H L 0 S protein NA staphylococcal nuclease COMPLEX (IMMUNOGLOBULIN/HYDROLASE) 06/06/95 THE CRYSTAL STRUCTURE OF ANTIBODY N10-STAPHYLOCOCCAL NUCLEASE COMPLEX AT 2.9 ANGSTROMS RESOLUTION STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Sheriff, S., Bossart-Whitaker, P. 2.8 X-RAY DIFFRACTION unknown 0.195 False False IGHV3 IGKV3 Kappa 1.00E-10 -13.63 1704035 4m7l H L 0 T protein NA tissue factor BLOOD CLOTTING/IMMUNE SYSTEM 08/12/13 Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 3.4 X-RAY DIFFRACTION 0.289 0.242 False True IGHV1 IGKV8 Kappa None None None None None 4qhu B A 0 D protein NA interleukin-17a IMMUNE SYSTEM 05/29/14 Crystal Structure of IL-17A/Fab6785 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Malia, T., Obmolova, G., Teplyakov, A. 2.2 X-RAY DIFFRACTION 0.216 0.171 False True IGHV3 IGLV3 Lambda None None None None None 2vxt H L 0 I protein NA interleukin-18 CYTOKINE 07/10/08 Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Argiriadi, M.A., Xiang, T., Wu, C., Ghayur, T., Borhani, D.W. 1.49 X-RAY DIFFRACTION 0.196 0.162 False True IGHV1 IGKV9 Kappa 5.33E-10 -12.64 19553661 1f90 H L 0 E peptide NA antigenic nonapeptide IMMUNE SYSTEM 07/06/00 FAB FRAGMENT OF MONOCLONAL ANTIBODY (LNKB-2) AGAINST HUMAN INTERLEUKIN-2 IN COMPLEX WITH ANTIGENIC PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Afonin, P.V., Fokin, A.V., Tsigannik, I.N., Mikhailova, I.Y., Onoprienko, L.V., Mikhaleva, I.I., Ivanov, V.T., Mareeva, T.Y., Nesmeyanov, V.A., Li, N., Duax, W.L., Pletnev, V.Z. 2.6 X-RAY DIFFRACTION 0.245 0.165 False False IGHV3 IGKV1 Kappa 1.19E-08 -10.8 11468348 1nak I M 0 Q peptide NA peptide mp1 IMMUNE SYSTEM 11/27/02 IGG1 FAB FRAGMENT (83.1) COMPLEX WITH 16-RESIDUE PEPTIDE (RESIDUES 304-321 OF HIV-1 GP120 (MN ISOLATE)) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Ghiara, J.B., Ollmann Saphire, E., Profy, A.T., Wilson, I.A. 2.57 X-RAY DIFFRACTION 0.326 0.288 False False IGHV3 IGKV1 Kappa None None None 3fn0 H L 0 P peptide NA envelope polyprotein gp160 IMMUNE SYSTEM 12/22/08 Crystal structure of HIV-1 neutralizing human Fab Z13e1 in complex with a 12-residue peptide containing the Z13e1 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Pejchal, R., Wilson, I.A., Zwick, M.B. 1.8 X-RAY DIFFRACTION 0.252 0.210 False True IGHV4 IGKV3 Kappa None None None 3o2d H L 0 A protein NA t-cell surface glycoprotein cd4 IMMUNE SYSTEM 07/22/10 Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Freeman, M.M., Seaman, M.S., Rits-Volloch, S., Hong, X., Ho, D.D., Chen, B. 2.19 X-RAY DIFFRACTION 0.224 0.192 False True IGHV1 IGKV4 Kappa None None None 3s37 H L 0 X protein NA vascular endothelial growth factor receptor 2 IMMUNE SYSTEM/Transferase 05/17/11 Structural basis for the function of two anti-VEGF receptor antibodies MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Franklin, M.C. 2.7 X-RAY DIFFRACTION 0.315 0.282 False True IGHV3 IGKV1 Kappa None None None 2aep H L 0 A protein NA neuraminidase IMMUNE SYSTEM 07/23/05 An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex. MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Venkatramani, L., Bochkareva, E., Lee, J.T., Gulati, U., Laver, W.G., Bochkarev, A., Air, G.M. 2.1 X-RAY DIFFRACTION 0.224 0.188 False False IGHV7 IGKV6 Kappa 1.20E-08 -10.8 16384583 4k8r D C 0 B protein NA proprotein convertase subtilisin/kexin type 9 IMMUNE SYSTEM 04/18/13 An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schiele, F., Nar, H. 3.22 X-RAY DIFFRACTION 0.226 0.167 False True IGHV3 IGKV1 Kappa None None None 3v6z A B 0 F protein NA e-antigen IMMUNE SYSTEM 12/20/11 Crystal Structure of Hepatitis B Virus e-antigen HEPATITIS B VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis b virus Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. 3.34 X-RAY DIFFRACTION 0.233 0.234 False False IGHV5 IGKV8 Kappa None None None 3i50 H L 0 E protein NA envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/03/09 Crystal structure of the West Nile Virus envelope glycoprotein in complex with the E53 antibody Fab WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Nybakken, G.E., Warren, J.T., Chen, B.R., Nelson, C.A., Fremont, D.H. 3.0 X-RAY DIFFRACTION 0.344 0.247 False True IGHV7 IGKV4 Kappa None None None 3f58 H L 0 P peptide NA protein (cyclic peptide (gp120)) IMMUNE SYSTEM 10/23/98 IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 12-RESIDUE CYCLIC PEPTIDE (INCLUDING RESIDUES 315-324 OF HIV-1 GP120 (MN ISOLATE); H315S MUTATION MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Cabezas, E., Satterthwait, A.C., Stura, E.A., Profy, A.T., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.200 False False IGHV3 IGKV3 Kappa None None None 4cmh B C 0 A protein NA adp-ribosyl cyclase 1 HYDROLASE/IMMUNE SYSTEM 01/15/14 Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Deckert, J., Wetzel, M.C., Park, P.U., Bartle, L.M., Skaletskaya, A., Goldmacher, V., Vallee, F., ZhouLiu, Q., Ferrari, P., Pouzieux, S., Lahoute, C., Dumontet, C., Plesa, A., Chiron, M., Lejeune, P., Chittenden, T., Blanc, V. 1.53 X-RAY DIFFRACTION 0.2082 0.1878 False False IGHV1 IGKV6 Kappa None None None None None 3k2u H L 0 A protein NA hepatocyte growth factor activator long chain HYDROLASE/IMMUNE SYSTEM 09/30/09 Crystal structure of HGFA in complex with the allosteric inhibitory antibody Fab40 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Ganesan, R., Eigenbrot, C., Shia, S. 2.35 X-RAY DIFFRACTION 0.290 0.239 False True IGHV3 IGKV1 Kappa 1.60E-10 -13.36 20004165 1e6j H L 0 P protein NA capsid protein p24 HIV CAPSID PROTEIN (P24) 08/18/00 Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (CLONE 12); MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus type 1(clone 12) Berthet-Colominas, C., Monaco, S., Novelli, A., Sibai, G., Mallet, F., Cusack, S. 3.0 X-RAY DIFFRACTION 0.284 0.210 False False IGHV1 IGKV4 Kappa 2.90E-08 -10.28 11080628 3cxd H L 0 P peptide NA a peptide from osteopontin IMMUNE SYSTEM 04/24/08 Crystal structure of anti-osteopontin antibody 23C3 in complex with its epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Du, J., Yang, H., Zhong, C., Ding, J. 2.8 X-RAY DIFFRACTION 0.292 0.248 False False IGHV10 IGKV12 Kappa None None None 4lkx A B 0 R peptide NA cemx segment IMMUNE SYSTEM 07/09/13 Humanized antibody 4B12 Fab complexed with a CemX segment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chu, H.M., Wright, J., Chan, Y.H., Lin, C.J., Chang, T.W., Lim, C. 1.92 X-RAY DIFFRACTION 0.229 0.180 False True IGHV4 IGKV1 Kappa None None None None None 1yjd H L 0 C protein NA t-cell-specific surface glycoprotein cd28 IMMUNE SYSTEM/SIGNALING PROTEIN 01/14/05 Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Evans, E.J., Esnouf, R.M., Manso-Sancho, R., Gilbert, R.J.C., James, J.R., Sorensen, P., Stuart, D.I., Davis, S.J. 2.7 X-RAY DIFFRACTION 0.282 0.239 False False IGHV1 IGKV15 Kappa None None None 4tvp D E 0 B protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 06/27/14 Structure of BG505 SOSIP.664 in complex with broadly neutralizing antibodies, PGT122 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Zhou, T., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.248 0.214 False True unknown unknown unknown None None None None None 3eo1 E D 0 F protein NA transforming growth factor beta-3 IMMUNE SYSTEM/CYTOKINE 09/26/08 Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Gruetter, C., Gruetter, M.G. 3.1 X-RAY DIFFRACTION 0.279 0.255 False True IGHV1 IGKV8 Kappa 2.50E-10 -13.09 19073914 4u6v H L 0 A protein NA alpha-hemolysin IMMUNE SYSTEM 07/29/14 Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS TCH60 homo sapiens homo sapiens staphylococcus aureus subsp. aureus tch60 Oganesyan, V.Y., Peng, L., Damschroder, M.M., Cheng, L., Sadowska, A., Tkaczyk, C., Sellman, B., Wu, H., Dall'Acqua, W.F. 2.56 X-RAY DIFFRACTION 0.235 0.198 False True IGHV3 IGKV1 Kappa None None None None None 4kvn H L 0 A protein NA hemagglutinin IMMUNE SYSTEM 05/22/13 Crystal structure of Fab 39.29 in complex with Influenza Hemagglutinin A/Perth/16/2009 (H3N2) HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Fong, R., Swem, L.R., Lupardus, P.J. 3.1 X-RAY DIFFRACTION 0.248 0.202 False True IGHV3 IGKV3 Kappa None None None 3sdy H L 0 B protein NA hemagglutinin ha2 chain Viral Protein/Immune System 06/09/11 Crystal Structure of Broadly Neutralizing Antibody CR8020 Bound to the Influenza A H3 Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.85 X-RAY DIFFRACTION 0.235 0.202 False True IGHV1 IGKV3 Kappa 1.00E-09 -12.48 21737702 4oii H L 0 A protein NA non-structural protein ns1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/14 West Nile Virus NS1 in complex with neutralizing 22NS1 antibody Fab WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Edeling, M.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.0 X-RAY DIFFRACTION 0.265 0.214 False True IGHV1 IGKV12 Kappa None None None None None 3sqo H L 0 A protein NA proprotein convertase subtilisin/kexin type 9 HYDROLASE/Immune system 07/05/11 PCSK9 J16 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Strop, P. 2.7 X-RAY DIFFRACTION 0.283 0.223 False True IGHV1 IGKV1D Kappa None None None 4zs6 C D 0 B protein NA s protein IMMUNE SYSTEM 05/13/15 Receptor binding domain and Fab complex HOMO SAPIENS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Yu, X., Wang, X. 3.166 X-RAY DIFFRACTION 0.245 0.203 False True IGHV3 IGKV1 Kappa None None None None None 2w9e H L 0 A protein NA major prion protein IMMUNE SYSTEM 01/23/09 Structure of ICSM 18 (anti-Prp therapeutic antibody) Fab fragment complexed with human Prp fragment 119-231 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Antonyuk, S.V., Trevitt, C.R., Strange, R.W., Jackson, G.S., Sangar, D., Batchelor, M., Jones, S., Georgiou, T., Cooper, S., Fraser, C., Khalili-Shirazi, A., Clarke, A.R., Hasnain, S.S., Collinge, J. 2.9 X-RAY DIFFRACTION 0.269 0.207 False False IGHV1 IGKV4 Kappa 1.00E-10 -13.63 19204296 2r4s H L 0 A protein NA beta-2 adrenergic receptor SIGNALING PROTEIN 08/31/07 Crystal structure of the human beta2 adrenoceptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K. 3.4 X-RAY DIFFRACTION 0.280 0.226 False False IGHV1 IGKV14 Kappa None None None 1ztx H L 0 E protein NA envelope protein Viral protein/Immune system 05/27/05 West Nile Virus Envelope Protein DIII in complex with neutralizing E16 antibody Fab WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Nybakken, G.E., Oliphant, T., Diamond, M.S., Fremont, D.H. 2.5 X-RAY DIFFRACTION 0.282 0.208 False False IGHV1 IGKV6 Kappa None None None 4leo A B 0 C protein NA receptor tyrosine-protein kinase erbb-3 Transferase/Immune System 06/26/13 Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Schiller C.B., Hopfner K.P. 2.64 X-RAY DIFFRACTION 0.258 0.228 False True IGHV1 IGKV4 Kappa None None None 1nfd F E 0 B protein NA n15 alpha-beta t-cell receptor COMPLEX (IMMUNORECEPTOR/IMMUNOGLOBULIN) 08/04/97 AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY MUS MUSCULUS mus musculus mus musculus mus musculus Wang, J.-H., Lim, K., Smolyar, A., Teng, M.-K., Sacchittini, J., Reinherz, E.L. 2.8 X-RAY DIFFRACTION 0.309 0.243 False True IGHV6 IGKV10 Kappa None None None 3ffd A B 0 P peptide NA parathyroid hormone-related protein IMMUNE SYSTEM/HORMONE 12/03/08 Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Mckinstry, W.J., Polekhina, G., Diefenbach-Jagger, H., Ho, P.W.M., Sato, K., Onuma, E., Gillespie, M.T., Martin, T.J., Parker, M.W. 2.0 X-RAY DIFFRACTION 0.271 0.224 False True IGHV5 IGLV3 Lambda None None None 4bkl A B 0 E peptide NA j1 epitope 04/26/13 Crystal structure of the arthritogenic antibody M2139 (Fab fragment) in complex with the triple-helical J1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Raposo, B., Dobritzsch, D., Ge, C., Ekman, D., Lindh, I., Foerster, M., Uysal, H., Schneider, G., Holmdahl, R. 3.25 X-RAY DIFFRACTION 0.26270 0.22175 False False IGHV1 IGKV3 Kappa None None None None None 2j88 H L 0 A protein NA hyalurononglucosaminidase HYDROLASE 10/23/06 Hyaluronidase in complex with a monoclonal IgG Fab fragment APIS MELLIFERA; SYNTHETIC CONSTRUCT mus musculus mus musculus apis mellifera Padavattan, S., Schirmer, T., Housley, Z.Markovic- 2.6 X-RAY DIFFRACTION 0.247 0.210 False False IGHV8 IGKV12 Kappa None None None 3l95 H L 0 Y protein NA neurogenic locus notch homolog protein 1 IMMUNE SYSTEM 01/04/10 Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Hymowitz, S.G., de Leon, G.P. 2.19 X-RAY DIFFRACTION 0.271 0.222 False True IGHV3 IGKV1 Kappa 2.50E-09 -11.73 20393564 2zpk H L 0 P peptide NA proteinase-activated receptor 4 IMMUNE SYSTEM 07/16/08 Crystal structure of P20.1 Fab fragment in complex with its antigen peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Nogi, T., Sanagawa, T., Takagi, J. 1.8 X-RAY DIFFRACTION 0.204 0.172 False False IGHV9 IGLV1 Lambda 1.47E-06 -7.95 18787202 4fp8 H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/21/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.947 X-RAY DIFFRACTION 0.241 0.212 False True IGHV3 IGKV1 Kappa None None None 2hrp H L 0 P peptide NA hiv-1 protease peptide COMPLEX (IMMUNOGLOBULIN/PEPTIDE) 12/27/96 ANTIGEN-ANTIBODY COMPLEX MUS MUSCULUS mus musculus mus musculus Lescar, J., Bentley, G.A. 2.2 X-RAY DIFFRACTION 0.289 0.198 False False IGHV5 IGKV3 Kappa 5.00E-09 -11.32 9150407 3mxw H L 0 A protein NA sonic hedgehog protein SIGNALING PROTEIN 05/07/10 Crystal structure Sonic hedgehog bound to the 5E1 fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G., Maun, H.R. 1.83 X-RAY DIFFRACTION 0.218 0.176 False True IGHV1 IGKV6 Kappa 7.00E-10 -12.7 20504762 3eff B A 0 M protein NA voltage-gated potassium channel MEMBRANE PROTEIN 09/08/08 The Crystal Structure of Full-Length KcsA in its Closed Conformation MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Uysal, S., Vasquez, V., Tereshko, T., Esaki, K., Fellouse,F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A. 3.8 X-RAY DIFFRACTION 0.331 0.270 False False IGHV3 IGKV1 Kappa None None None 4jan A B 0 I protein NA envelope glycoprotein gp120 of hiv-1 clade c viral protein/immune system 02/18/13 crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D. 3.15 X-RAY DIFFRACTION 0.256 0.196 False True IGHV4 IGLV3 Lambda None None None 4ot1 H L 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/13/14 Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by the Neutralizing Human Antibody SM5-1 HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS homo sapiens homo sapiens human cytomegalovirus Diestel, U., Muller, Y.A. 2.11 X-RAY DIFFRACTION 0.231 0.171 False True IGHV1 IGLV1 Lambda None None None None None 4dkf H L 0 A protein NA interleukin-34 CYTOKINE/IMMUNE SYSTEM 02/03/12 Crystal Structure of Human Interleukin-34 Bound to FAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ma, X., Chen, Y., Stawicki, S., Wu, Y., Bazan, J.F., Starovasnik, M.A. 2.61 X-RAY DIFFRACTION 0.256 0.225 False True IGHV3 IGKV1 Kappa None None None 1qkz H L 0 P peptide NA major outer membrane protein p1.16 IMMUNE SYSTEM 08/17/99 Fab fragment (MN14C11.6) in complex with a peptide antigen derived from Neisseria meningitidis P1.7 serosubtype antigen and domain II from Streptococcal protein G STREPTOCOCCUS SP.; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Derrick, J.P., Feavers, I., Maiden, M.C.J. 1.95 X-RAY DIFFRACTION 0.262 0.205 False False IGHV5 IGKV1 Kappa None None None 2bdn H L 0 A protein NA small inducible cytokine a2 immune system 10/20/05 Crystal structure of human MCP-1 bound to a blocking antibody, 11K2 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Boriack-Sjodin, P.A., Rushe, M., Reid, C., Jarpe, M, van Vlijmen, H, Bailly, V. 2.53 X-RAY DIFFRACTION 0.277 0.219 False True IGHV14 IGKV13 Kappa 4.60E-12 -15.46 16682434 4etq H L 0 C protein NA imv membrane protein IMMUNE SYSTEM/VIRAL PROTEIN 04/24/12 Vaccinia virus D8L IMV envelope protein in complex with Fab of murine IgG2a LA5 MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus Matho, M.H., Zajonc, D.M. 2.1 X-RAY DIFFRACTION 0.252 0.202 False True IGHV1 IGKV4 Kappa None None None 4xi5 D C 0 B protein NA envelope glycoprotein l Viral Protein/Immune System 01/06/15 gHgL of varicella-zoster virus in complex with human neutralizing antibodies HUMAN HERPESVIRUS 3 STRAIN OKA VACCINE; HOMO SAPIENS homo sapiens homo sapiens human herpesvirus 3 strain oka vaccine Xing, Y. 3.9 X-RAY DIFFRACTION 0.276 0.245 False True IGHV3 IGKV1 Kappa None None None None None 2eh8 H L 0 P peptide NA pres1/pres2/surface protein IMMUNE SYSTEM 03/05/07 Crystal structure of the complex of humanized KR127 fab and PRES1 peptide epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Chi, S.-W., Kim, S.-J., Maeng, C.-Y., Hong, H.J., Ryu, S.-E. 2.6 X-RAY DIFFRACTION 0.258 0.193 False True IGHV1 IGKV1 Kappa 1.10E-08 -11.29 17517649 1cu4 H L 0 P peptide NA recognition peptide IMMUNE SYSTEM 08/20/99 CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kanyo, Z.F., Pan, K.M., Williamson, R.A., Burton, D.R., Prusiner, S.B., Fletterick, R.J., Cohen, F.E. 2.9 X-RAY DIFFRACTION 0.268 0.159 False False IGHV14 IGKV1 Kappa None None None 3qg6 B A 0 D peptide NA agr autoinducing peptide IMMUNE SYSTEM/INHIBITOR 01/24/11 Structural Basis for Ligand Recognition and Discrimination of a Quorum Quenching Antibody MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kirchdoerfer, R.N., Janda, J.D., Kaufmann, G.F, Wilson, I.A 2.5 X-RAY DIFFRACTION 0.239 0.184 False True IGHV3 IGKV1 Kappa None None None 2v17 H L 0 A peptide NA peptide fragment IMMUNE SYSTEM 05/22/07 Structure of the complex of antibody MN423 with a fragment of tau protein HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Sevcik, J., Skrabana, R., Csokova, N., Dvorsky, R., Novak, M. 1.65 X-RAY DIFFRACTION 0.218 0.156 False False IGHV7 IGKV16 Kappa None None None 1ejo H L 0 P peptide NA fmdv peptide IMMUNE SYSTEM 03/03/00 FAB FRAGMENT OF NEUTRALISING MONOCLONAL ANTIBODY 4C4 COMPLEXED WITH G-H LOOP FROM FMDV. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Ochoa, W.F., Kalko, S.G., Gomes, P., Fita, I., Verdaguer, N. 2.3 X-RAY DIFFRACTION 0.262 0.248 False False IGHV5 IGKV3 Kappa None None None 1ikf H L 0 C peptide NA cyclosporin a IMMUNE SYSTEM/IMMUNOSUPPRESSANT 12/09/93 A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens tolypocladium inflatum Vix, O., Altschuh, D., Rees, B., Thierry, J.-C. 2.5 X-RAY DIFFRACTION unknown 0.164 False True IGHV5 IGKV10 Kappa None None None 1qfw H L 0 A protein NA gonadotropin alpha subunit IMMUNE SYSTEM 04/15/99 TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Tegoni, M., Spinelli, S., Cambillau, C. 3.5 X-RAY DIFFRACTION 0.310 0.260 False True IGHV1 IGKV3 Kappa None None None 4qci H L 0 C protein NA platelet-derived growth factor subunit b CYTOKINE/CYTOKINE RECEPTOR 05/12/14 PDGF-B blocking antibody bound to PDGF-BB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kuai, J., Mosyak, L., Tam, M., LaVallie, E., Pullen, N., Carven, G. 2.3 X-RAY DIFFRACTION 0.247 0.211 False True IGHV3 IGLV3 Lambda None None None None None 4qww D C 0 B protein NA acetylcholinesterase HYDROLASE/IMMUNE SYSTEM 07/17/14 Crystal structure of the Fab410-BfAChE complex BUNGARUS FASCIATUS; MUS MUSCULUS mus musculus mus musculus bungarus fasciatus Bourne, Y., Renault, L., Marchot, P. 2.7 X-RAY DIFFRACTION 0.239 0.199 False False IGHV10 IGKV4 Kappa None None None None None 1e4x I M 0 Q peptide NA cyclic peptide IMMUNE SYSTEM 07/12/00 crossreactive binding of a circularized peptide to an anti-TGFalpha antibody Fab-fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Hahn, M., Winkler, D., Misselwitz, R., Wessner, H., Welfle, K., Zahn, G., Schneider-Mergener, J., Hoehne, W. 1.9 X-RAY DIFFRACTION 0.311 0.245 False False IGHV1 IGKV10 Kappa None None None 2qqk H L 0 A protein NA neuropilin-2 SIGNALING PROTEIN 07/26/07 Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Appleton, B.A., Wiesmann, C. 2.75 X-RAY DIFFRACTION 0.243 0.186 False True IGHV3 IGKV1 Kappa None None None 3v4v M N 0 D protein NA integrin beta-7 CELL ADHESION 12/15/11 crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yu, Y., Zhu, J., Springer, T.A. 3.1 X-RAY DIFFRACTION 0.231 0.197 False True IGHV1 IGKV1 Kappa None None None 3opz I M 0 B protein NA trans-sialidase hydrolase/immune system 09/02/10 Crystal structure of trans-sialidase in complex with the Fab fragment of a neutralizing monoclonal IgG antibody TRYPANOSOMA CRUZI; MUS MUSCULUS mus musculus mus musculus trypanosoma cruzi Larrieux, N., Muia, R., Campetella, O., Buschiazzo, A. 3.4 X-RAY DIFFRACTION 0.205 0.164 False False IGHV1 IGKV4 Kappa None None None 3t2n H L 0 A protein NA serine protease hepsin HYDROLASE 07/22/11 Human hepsin protease in complex with the Fab fragment of an inhibitory antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Koschubs, T., Dengl, S., Duerr, H., Kaluza, K., Georges, G., Hartl, C., Jennewein, S., Lanzendoerfer, M., Auer, J., Stern, A., Huang, K.-S., Kostrewa, D., Ries, S., Hansen, S., Kohnert, U., Cramer, P., Mundigl, O. 2.55 X-RAY DIFFRACTION 0.275 0.242 False True IGHV7 IGLV7 Lambda 3.98e-08 -10.5 SPR 37 22132769 1tqb B C 0 A protein NA prion protein UNKNOWN FUNCTION/IMMUNE SYSTEM 06/17/04 Ovine recombinant PrP(114-234), VRQ variant in complex with the Fab of the VRQ14 antibody OVIS ARIES; MUS MUSCULUS mus musculus mus musculus ovis aries Eghiaian, F., Grosclaude, J., Debey, P., Doublet, B., Treguer, E., Rezaei, H., Knossow, M. 2.55 X-RAY DIFFRACTION 0.268 0.214 False True IGHV9 IGKV1 Kappa None None None 3d85 B A 0 C protein NA interleukin-23 subunit p19 IMMUNE SYSTEM/CYTOKINE 05/22/08 Crystal structure of IL-23 in complex with neutralizing FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V. 1.9 X-RAY DIFFRACTION 0.214 0.171 False False IGHV1 IGKV5 Kappa None None None 1adq H L 0 A protein NA igg4 rea fc COMPLEX (IMMUNOGLOBULIN/AUTOANTIGEN) 02/18/97 CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC HOMO SAPIENS homo sapiens homo sapiens homo sapiens Corper, A.L., Taussig, M.J., Sutton, B.J. 3.15 X-RAY DIFFRACTION 0.289 0.225 False False IGHV3 IGLV3 Lambda None None None 3wkm I M 0 B protein NA putative zinc metalloprotease aq_1964 HYDROLASE 10/28/13 The periplasmic PDZ tandem fragment of the RseP homologue from Aquifex aeolicus in complex with the Fab fragment AQUIFEX AEOLICUS; MUS MUSCULUS mus musculus mus musculus aquifex aeolicus Nogi, T., Tabata, S., Tamura-kawakami, K., Takagi, J. 2.2 X-RAY DIFFRACTION 0.272 0.224 False False IGHV14 IGKV3 Kappa None None None None None 4ioi B A 0 H protein NA immunoglobulin g-binding protein a immune system 01/07/13 Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC HOMO SAPIENS; STAPHYLOCOCCUS AUREUS; FINEGOLDIA MAGNA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens staphylococcus aureus Bzymek, K.P., Zer, C., Avery, K.N., Williams, J.C. 1.95 X-RAY DIFFRACTION 0.204 0.176 False True IGHV3 IGKV1 Kappa None None None 4hcr H L 0 A protein NA mucosal addressin cell adhesion molecule 1 IMMUNE SYSTEM 10/01/12 Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Springer, T., Yu, Y., Zhu, J. 2.3 X-RAY DIFFRACTION 0.208 0.153 False True IGHV1 IGKV2D Kappa None None None 4jhw H L 0 F protein NA fusion glycoprotein f0 IMMUNE SYSTEM 03/05/13 Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS homo sapiens homo sapiens human respiratory syncytial virus Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S. 3.6 X-RAY DIFFRACTION 0.267 0.213 False True IGHV1 IGKV1 Kappa None None None 1pz5 B A 0 C peptide NA octapeptide (mdwnmhaa) IMMUNE SYSTEM 07/09/03 Structural basis of peptide-carbohydrate mimicry in an antibody combining site MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Vyas, N.K., Vyas, M.N., Chervenak, M.C., Bundle, D.R., Pinto, B.M., Quiocho, F.A. 1.8 X-RAY DIFFRACTION 0.254 0.219 False False IGHV6 IGKV1 Kappa 4.00E-06 -7.8 14645714 1ob1 B A 0 C protein NA major merozoite surface protein IMMUNE SYSTEM 01/22/03 Crystal structure of a Fab complex whith Plasmodium falciparum MSP1-19 PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Pizarro, J.C., Chitarra, V., Verger, D., Holm, I., Petres, S., Dartville, S., Nato, F., Longacre, S., Bentley, G.A. 2.9 X-RAY DIFFRACTION 0.288 0.257 False False IGHV9 IGKV4 Kappa 2.00E-10 -12.29 12729744 3skj I M 0 F protein NA ephrin type-a receptor 2 IMMUNE SYSTEM 06/22/11 Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., Wu, H., Dall'Acqua, W.F. 2.5 X-RAY DIFFRACTION 0.271 0.216 False True IGHV3 IGKV1 Kappa 8.10E-10 -12.4 21867711 4jzj H L 0 C protein NA interleukin-3 receptor subunit alpha CYTOKINE RECEPTOR/IMMUNE SYSTEM 04/03/13 Crystal Structure of Receptor-Fab Complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Broughton, S.E., Parker, M.W. 2.801 X-RAY DIFFRACTION 0.244 0.185 False False IGHV5 IGKV4 Kappa None None None None None 2vwe L J 0 B protein NA vascular endothelial growth factor b IMMUNE SYSTEM 06/23/08 Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Leonard, P., Scotney, P.D., Jabeen, T., Iyer, S., Fabri, L.J., Nash, A.D., Acharya, K.R. 3.4 X-RAY DIFFRACTION 0.310 0.262 False True IGHV1 IGKV10 Kappa 1.14E-10 -13.56 18930733 4d9r E D 0 B protein NA complement factor d HYDROLASE/IMMUNE SYSTEM 01/11/12 Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murray, J.M., Wiesmann, C. 2.42 X-RAY DIFFRACTION 0.251 0.213 False True IGHV7 IGKV1 Kappa None None None 3v6o C E 0 A protein NA leptin receptor IMMUNE SYSTEM 12/20/11 Leptin Receptor-antibody complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Carpenter, B., Hemsworth, G.R., Ross, R.J., Artymiuk, P.J. 1.95 X-RAY DIFFRACTION 0.213 0.171 False False IGHV2 IGKV6 Kappa None None None 3g6j F E 0 B protein NA complement c3 alpha chain IMMUNE SYSTEM 02/06/09 C3b in complex with a C3b specific Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.1 X-RAY DIFFRACTION 0.282 0.214 False True IGHV3 IGKV1 Kappa 1.90E-09 -11.89 19196712 1ce1 H L 0 P peptide NA protein (peptide antigen) ANTIBODY 03/12/99 1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN ESCHERICHIA COLI; SYNTHETIC CONSTRUCT James, L.C., Hale, G., Waldmann, H., Bloomer, A.C. 1.9 X-RAY DIFFRACTION 0.270 0.220 False True IGHV4 IGKV1 Kappa None None None 3jwd H L 0 A protein NA hiv-1 gp120 envelope glycoprotein VIRAL PROTEIN 09/18/09 Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Majeed, S., Ban, Y.A., Chen, L., Huang, C.C., Kong, L., Kwon, Y.D., Stuckey, J., Zhou, T., Robinson, J.E., Schief, W.R., Sodroski, J., Wyatt, R., Kwong, P.D. 2.61 X-RAY DIFFRACTION 0.275 0.201 False True IGHV1 IGKV1 Kappa None None None 1nmb H L 0 N protein NA n9 neuraminidase COMPLEX (HYDROLASE/IMMUNOGLOBULIN) 01/17/95 THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Malby, R.L., Tulip, W.R., Colman, P.M. 2.2 X-RAY DIFFRACTION unknown 0.210 False False IGHV1 IGKV10 Kappa None None None 2j6e H L 0 A protein NA ig gamma-1 chain c region IMMUNE SYSTEM 09/28/06 Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation HOMO SAPIENS homo sapiens homo sapiens homo sapiens Duquerroy, S., Stura, E.A., Bressanelli, S., Browne, H., Beale, D., Hamon, M., Casali, P., Vaney, M.-C., Rey, F.A., Sutton, B.J., Taussig, M.J. 3.0 X-RAY DIFFRACTION 0.2877 0.2234 False True IGHV4 IGLV1 Lambda None None None 3l5x H L 0 A protein NA interleukin-13 IMMUNE SYSTEM 12/22/09 Crystal structure of the complex between IL-13 and H2L6 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.247 0.197 False True IGHV2 IGKV3 Kappa 2.69E-10 -13.05 20226193 2zuq C B 0 A protein NA disulfide bond formation protein b Oxidoreductase/IMMUNE SYSTEM 10/28/08 Crystal structure of DsbB-Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Inaba, K., Suzuki, M., Murakami, S. 3.3 X-RAY DIFFRACTION 0.351 0.275 False False IGHV5 IGKV8 Kappa None None None 1sy6 H L 0 A protein NA t-cell surface glycoprotein cd3 gamma/epsilonchain signaling protein/antibiotic 03/31/04 Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Kjer-Nielsen, L., Dunstone, M.A., Kostenko, L., Ely, L.K., Beddoe, T., Misfud, N.A., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J. 2.1 X-RAY DIFFRACTION 0.255 0.211 False True IGHV1 IGKV4 Kappa 2.73E-06 -7.59 15136729 3mlz H L 0 P peptide NA hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with a VI191 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.99 X-RAY DIFFRACTION 0.330 0.191 False False IGHV4 IGLV1 Lambda None None None 4m8q H L 0 C protein NA 4e10 epitope scaffold t117 IMMUNE SYSTEM 08/13/13 Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Finton, K.A.K. 2.89 X-RAY DIFFRACTION 0.302 0.261 False True IGHV1 IGKV3 Kappa None None None None None 4r8w H L 0 B protein NA hemagglutinin IMMUNE SYSTEM 09/03/14 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a neutralizing antibody CT149 INFLUENZA A VIRUS (A/ANHUI/1-BALF_RG45/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1-balf_rg45/2013(h7n9)) Wu, Y., Shi, Y., Qi, J., Gao, G.F. 2.795 X-RAY DIFFRACTION 0.311 0.262 False True IGHV1 IGKV3 Kappa None None None None None 4oqt H L 0 A protein NA leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/10/14 LINGO-1/Li81 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pepinsky, R.B., Arndt, J.W., Quan, C., Gao, Y., Quintero-Monzon, O., Lee, X., Mi, S. 3.23 X-RAY DIFFRACTION 0.256 0.192 False True IGHV3 IGKV3 Kappa None None None None None 3cvh Q R 0 M protein NA h-2 class i histocompatibility antigen, k-b alpha chain IMMUNE SYSTEM 04/18/08 How TCR-like antibody recognizes MHC-bound peptide MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus mus musculus Mareeva, T., Martinez-Hackert, E., Sykulev, Y. 2.9 X-RAY DIFFRACTION 0.296 0.219 False False IGHV1 IGKV13 Kappa None None None 3sge H L 0 K peptide NA r13 peptide IMMUNE SYSTEM 06/14/11 Crystal structure of mAb 17.2 in complex with R13 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Pizarro, J.C., Boulot, G., Hontebeyrie, M., Bentley, G.A. 1.89 X-RAY DIFFRACTION 0.211 0.179 False True IGHV10 IGKV1 Kappa None None None 2zjs H L 0 Y protein NA preprotein translocase secy subunit PROTEIN TRANSPORT/IMMUNE SYSTEM 03/08/08 Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment THERMUS THERMOPHILUS; MUS MUSCULUS mus musculus mus musculus thermus thermophilus Tsukazaki, T., Mori, H., Fukai, S., Ishitani, R., Perederina, A., Vassylyev, D.G., Ito, K., Nureki, O. 3.2 X-RAY DIFFRACTION 0.280 0.244 False True IGHV1 IGKV10 Kappa None None None 3hi6 X Y 0 B protein NA integrin alpha-l cell adhesion/immune system 05/19/09 Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhang, H., Wang, J. 2.3 X-RAY DIFFRACTION 0.226 0.170 False True IGHV3 IGKV1 Kappa 4.70E-06 -7.26 19805116 2yc1 A B 0 C protein NA beta-mammal toxin cn2 IMMUNE SYSTEM/TOXIN 03/10/11 Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann HOMO SAPIENS; CENTRUROIDES NOXIUS HOFFMANN homo sapiens homo sapiens centruroides noxius hoffmann Canul-Tec, J.C., Riano-Umbarila, L., Rudino-Pinera, E., Becerril, B., Possani, L.D., Torres-Larios, A. 1.9 X-RAY DIFFRACTION 0.21212 0.18613 False True IGHV3 IGKV3 Kappa None None None 2r0z H L 0 Q peptide NA gripi peptide fragment IMMUNE SYSTEM 08/21/07 PFA1 FAB complexed with GripI peptide fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Gardberg, A.S., Dealwis, C. 2.096 X-RAY DIFFRACTION 0.261 0.201 False False IGHV8 IGKV1 Kappa 3.40E-06 -7.33 17895381 3p30 H L 0 A protein NA hiv-1 gp41 IMMUNE SYSTEM 10/04/10 crystal structure of the cluster II Fab 1281 in complex with HIV-1 gp41 ectodomain HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Frey, G., Chen, J., Rits-Volloch, S., Freeman, M.M., Zolla-Pazner, S., Chen, B. 3.3 X-RAY DIFFRACTION 0.289 0.261 False True IGHV1 IGLV1 Lambda None None None 4jr9 H L 0 A protein NA nitrite extrusion protein 1 TRANSPORT PROTEIN/Immune System 03/21/13 Crystal structure of nitrate/nitrite exchanger NarK ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Zheng, H., Wisedchaisri, G., Gonen, T. 2.6 X-RAY DIFFRACTION 0.261 0.229 False False IGHV9 IGKV19 Kappa None None None 4ag4 H L 0 A protein NA epithelial discoidin domain-containing receptor 1 IMMUNE SYSTEM/TRANSFERASE 01/24/12 Crystal structure of a DDR1-Fab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Carafoli, F., Mayer, M.C., Shiraishi, K., Pecheva, M.A., Chan, L.Y., Nan, R., Leitinger, B., Hohenester, E. 2.8 X-RAY DIFFRACTION 0.2855 0.2156 False False IGHV1 IGKV4 Kappa None None None 3u9u A B 0 F protein NA receptor tyrosine-protein kinase erbb-4 Transferase 10/19/11 Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Hollmen, M., Liu, P., Wildiers, H., Reinvall, I., Vandorpe, T., Smeets, A., Deraedt, K., Vahlberg, T., Joensuu, H., Leahy, D.J., Schoffski, P., Elenius, K. 3.42 X-RAY DIFFRACTION 0.272 0.234 False True IGHV8 IGKV1 Kappa None None None 4m1g H L 0 B protein NA a33r IMMUNE SYSTEM 08/02/13 Structure of murine IgG2a A27D7-Fab in complex with vaccinia antigen A33R at the resolution of 1.6 Angstroms MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus Matho, M.H., Schlossman, A.M., Zajonc, D.M. 1.6 X-RAY DIFFRACTION 0.226 0.201 False True IGHV2 IGKV4 Kappa None None None None None 4lmq H L 0 D protein NA stromal cell-derived factor 1 cell adhesion/immune system 07/10/13 Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhong, Z., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., Wong, T, Chiang, N.Y., Clark, S., Clark, R., Quintana, L., Gribling, P., Suto, E., Barck, K., Corpuz, R., Yao, J., Takkar, R., Lee, W.P., Damico-Beyer, L.A., Carano, R.D., Adams, C., Kelley, R.F., Wang, W., Ferrara, N. 2.773 X-RAY DIFFRACTION 0.301 0.253 False True IGHV3 IGKV1 Kappa None None None None None 1i9r K M 0 B protein NA cd40 ligand CYTOKINE/IMMUNE SYSTEM 03/20/01 STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY HOMO SAPIENS homo sapiens homo sapiens homo sapiens Karpusas, M., Lucci, J., Ferrant, J., Benjamin, C., Hsu, Y.-M. 3.1 X-RAY DIFFRACTION 0.285 0.233 False False IGHV1 IGKV3D Kappa None None None 3rkd H L 0 A protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 04/18/11 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Sivaraman, J. 1.9 X-RAY DIFFRACTION 0.217 0.189 False False IGHV8 IGKV12 Kappa 5.89E-09 -11.22 21642534 4fqj H L 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Influenza B/Florida/4/2006 hemagglutinin Fab CR8071 complex INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dreyfus, C., Laursen, N.S., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.265 0.230 False True IGHV1 IGLV1 Lambda None None None 4hc1 H L 0 A protein NA mucosal addressin cell adhesion molecule 1 IMMUNE SYSTEM 09/28/12 Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Springer, T., Yu, Y., Zhu, J. 2.871 X-RAY DIFFRACTION 0.253 0.200 False True IGHV3 IGKV14 Kappa None None None 3wfd H L 0 B protein NA nitric oxide reductase subunit b IMMUNE SYSTEM/OXIDOREDUCTASE 07/18/13 Reduced and acetaldoxime-bound cytochrome c-dependent nitric oxide reductase (cNOR) from Pseudomonas aeruginosa in complex with antibody fragment MUS MUSCULUS; PSEUDOMONAS AERUGINOSA mus musculus mus musculus pseudomonas aeruginosa Sato, N., Ishii, S., Hino, T., Sugimoto, H., Fukumori, Y., Shiro, Y., Tosha, T. 2.3 X-RAY DIFFRACTION 0.232 0.191 False False IGHV1 IGKV16 Kappa None None None None None 3u30 C B 0 A protein NA linear di-ubiquitin IMMUNE SYSTEM 10/04/11 Crystal structure of a linear-specific Ubiquitin fab bound to linear ubiquitin HOMO SAPIENS homo sapiens homo sapiens homo sapiens Matsumoto, M.L., Dong, K.C., Yu, C., Phu,L, Gao, X., Hannoush, R.N., Hymowitz, S.G., Kirkpatrick, D.S., Dixit, V.M., Kelley, R.F. 2.428 X-RAY DIFFRACTION 0.258 0.229 False True IGHV3 IGKV1 Kappa None None None 4hwb H L 0 A protein NA interleukin-13 receptor subunit alpha-1 IMMUNE SYSTEM 11/07/12 Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xu, Y. 2.61 X-RAY DIFFRACTION 0.224 0.197 False True IGHV5 IGKV3 Kappa None None None 4ywg I M 0 Q protein NA scaffold hiv-1 gp120 v1v2 region derived from strain zm109 Viral protein/Immune system 03/20/15 Crystal structure of 830A in complex with V1V2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Pan, R., Kong, X. 2.998 X-RAY DIFFRACTION 0.296 0.219 False True IGHV4 IGKV3 Kappa None None None None None 4i18 H L 0 C protein NA prolactin receptor CYTOKINE, SIGNALING PROTEIN 11/20/12 Crystal structure of human prolactin receptor complexed with Fab fragment MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Duguid, E.M., Mukherjee, S., Kouadio, J.L. 3.238 X-RAY DIFFRACTION 0.246 0.191 False True IGHV3 IGKV1 Kappa None None None None None 3ks0 K J 0 A protein NA cytochrome b2, mitochondrial OXIDOREDUCTASE 11/20/09 Crystal structure of the heme domain of flavocytochrome b2 in complex with Fab B2B4 SACCHAROMYCES CEREVISIAE; MUS MUSCULUS mus musculus mus musculus saccharomyces cerevisiae Golinelli-Pimpaneau, B., Lederer, F., Le, K.H.D. 2.7 X-RAY DIFFRACTION 0.289 0.214 False False IGHV3 IGLV1 Lambda None None None 1cfn B A 0 C peptide NA protein (bound peptide) POLYSPECIFICITY 03/19/99 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-RELATED PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J., Hoehne, W. 2.65 X-RAY DIFFRACTION 0.325 0.277 False False IGHV1 IGKV14 Kappa None None None 4np4 H L 0 A protein NA toxin b IMMUNE SYSTEM 11/20/13 Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab CLOSTRIDIUM DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens clostridium difficile Orth, P., Xiao, L., Hernandez, L.D., Reichert, P., Sheth, P., Beaumont, M., Murgolo, N., Ermakov, G., DiNunzio, E., Racine, F., Karczewski, J., Secore, S., Ingram, R.N., Mayhood, T., Strickland, C., Therien, A.G. 2.89 X-RAY DIFFRACTION 0.232 0.198 False False IGHV5 IGKV3 Kappa None None None None None 4liq H L 0 E protein NA macrophage colony-stimulating factor 1 receptor IMMUNE SYSTEM 07/03/13 Structure of the extracellular domain of human CSF-1 receptor in complex with the Fab fragment of RG7155 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Benz, J., Gorr, I.H., Hertenberger, H., Ries, C.H. 2.6 X-RAY DIFFRACTION 0.237 0.186 False True IGHV1 IGKV1 Kappa None None None None None 4jpk H L 0 A protein NA germline-targeting hiv-1 gp120 engineered outer domain,eod-gt6 IMMUNE SYSTEM/VIRAL PROTEIN 03/19/13 Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 Julien, J.-P., Jardine, J., Schief, W.R., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.263 0.200 False True IGHV1 IGKV3 Kappa None None None 4nx3 B A 0 D protein NA hcv e2 IMMUNE SYSTEM/VIRAL PROTEIN 12/08/13 Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 HEPATITIS C VIRUS SUBTYPE 2A; MUS MUSCULUS mus musculus mus musculus hepatitis c virus subtype 2a Khan, A.G., Miller, M.T., Marcotrigiano, J. 2.4 X-RAY DIFFRACTION 0.261 0.198 False True IGHV14 IGKV8 Kappa None None None None None 2q8b H L 0 A protein NA apical membrane antigen 1 Immune System 06/10/07 Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Gupta, A., Murphy, V.J., Anders, R.F., Batchelor, A.H. 2.3 X-RAY DIFFRACTION 0.256 0.209 False False IGHV14 IGKV6 Kappa None None None 1cz8 H L 0 W protein NA vascular endothelial growth factor IMMUNE SYSTEM 09/01/99 VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B. 2.4 X-RAY DIFFRACTION 0.267 0.208 False True IGHV7 IGKV1 Kappa 1.10E-10 -14.12 10543973 1n8z B A 0 C protein NA receptor protein-tyrosine kinase erbb-2 TRANSFERASE 11/21/02 Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cho, H.-S., Mason, K., Ramyar, K.X., Stanley, A.M., Gabelli, S.B., Denney Jr., D.W., Leahy, D.J. 2.52 X-RAY DIFFRACTION 0.284 0.222 False True IGHV3 IGKV1 Kappa None None None